Gold compounds as therapeutic agents for human diseases

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Title Gold compounds as therapeutic agents for human diseases
Author Berners-Price, Sue; Filipovska, Aleksandra
Journal Name Metallomics
Year Published 2011
Place of publication United Kingdom
Publisher Royal Society of Chemistry
Abstract The application of gold in medicine is traceable for several thousand years and Au(I) compounds have been used clinically to treat rheumatoid arthritis since the last century. Recently research into gold-based drugs for a range of human diseases has seen a renaissance. Old as well as new Au(I) and Au(III) compounds have been used and designed with an aim of targeting cellular components that are implicated in the onset or progression of cancers, rheumatoid arthiritis, viral and parasitic diseases. In addition, new disease targets have been found for gold compounds that have given insight into the mechanism of action of these compounds, as well as in the molecular pathophysiology of human diseases. Here we discuss the rationale for the design and use of gold compounds that have specific and selective targets in cells to alleviate the symptoms of a range of human diseases. We summarise the most recent findings in this research and our own discoveries to show that gold compounds can be developed to become versatile and powerful drugs for diseases caused by dysfunction of selenol and thiol containing proteins.
Peer Reviewed Yes
Published Yes
Alternative URI http://dx.doi.org/10.1039/c1mt00062d
Volume 3
Issue Number 9
Page from 863
Page to 873
ISSN 1756-5901
Date Accessioned 2012-01-28; 2012-02-16T05:35:22Z
Date Available 2012-02-16T05:35:22Z
Research Centre Institute for Glycomics
Faculty Faculty of Science, Environment, Engineering and Technology
Subject Bioinorganic Chemistry
URI http://hdl.handle.net/10072/42797
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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