Show simple item record

dc.contributor.authorMicallef, Leanne S
dc.contributor.authorLoughrey, Bradley T
dc.contributor.authorHealy, Peter C
dc.contributor.authorParsons, Peter G
dc.contributor.authorWilliams, Michael L
dc.date.accessioned2017-05-03T11:09:49Z
dc.date.available2017-05-03T11:09:49Z
dc.date.issued2011
dc.date.modified2012-02-16T05:37:31Z
dc.identifier.issn0276-7333
dc.identifier.doi10.1021/om100928s
dc.identifier.urihttp://hdl.handle.net/10072/42806
dc.description.abstractThis article outlines the synthesis and characterization of a structurally diverse range of mono- and 1,10-disubstituted ruthenocenyl complexes. Compounds were prepared through organic manipulation of ruthenocenefluorocarbonyl and carboxylic acid functional groups and via the Friedel-Crafts acylation of ruthenocene. A dimetalated acid anhydride of the formula [Ru(?5-C5H5)(?5-C5H4-CO)]2O was also prepared, and the X-ray structure of this molecule is reported. Complexes were evaluated for their antiproliferative properties against a range of tumorigenic cell lines and a control human fibroblast, with results indicating these organoruthenium metallocenes to possess moderate to weak cytotoxicity toward cancerous cells.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherAmerican Chemical Society
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom1395
dc.relation.ispartofpageto1403
dc.relation.ispartofissue6
dc.relation.ispartofjournalOrganometallics
dc.relation.ispartofvolume30
dc.rights.retentionY
dc.subject.fieldofresearchInorganic chemistry
dc.subject.fieldofresearchBiologically active molecules
dc.subject.fieldofresearchOrganic chemistry
dc.subject.fieldofresearchOther chemical sciences
dc.subject.fieldofresearchOrganometallic chemistry
dc.subject.fieldofresearchcode3402
dc.subject.fieldofresearchcode340401
dc.subject.fieldofresearchcode3405
dc.subject.fieldofresearchcode3499
dc.subject.fieldofresearchcode340209
dc.titleMono- and 1,1'-Disubstituted Organoruthenium Cyclopentadiene Complexes: Synthesis, Structural Characterization, and Antitumoral Evaluation
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.rights.copyrightSelf-archiving of the author-manuscript version is not yet supported by this journal. Please refer to the journal link for access to the definitive, published version or contact the author[s] for more information.
gro.date.issued2011
gro.hasfulltextNo Full Text
gro.griffith.authorHealy, Peter C.


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record