dc.contributor.author | Micallef, Leanne S | |
dc.contributor.author | Loughrey, Bradley T | |
dc.contributor.author | Healy, Peter C | |
dc.contributor.author | Parsons, Peter G | |
dc.contributor.author | Williams, Michael L | |
dc.date.accessioned | 2017-05-03T11:09:49Z | |
dc.date.available | 2017-05-03T11:09:49Z | |
dc.date.issued | 2011 | |
dc.date.modified | 2012-02-16T05:37:31Z | |
dc.identifier.issn | 0276-7333 | |
dc.identifier.doi | 10.1021/om100928s | |
dc.identifier.uri | http://hdl.handle.net/10072/42806 | |
dc.description.abstract | This article outlines the synthesis and characterization of a structurally diverse range of mono- and 1,10-disubstituted ruthenocenyl complexes. Compounds were prepared through organic manipulation of ruthenocenefluorocarbonyl and carboxylic acid functional groups and via the Friedel-Crafts acylation of ruthenocene. A dimetalated acid anhydride of the formula [Ru(?5-C5H5)(?5-C5H4-CO)]2O was also prepared, and the X-ray structure of this molecule is reported. Complexes were evaluated for their antiproliferative properties against a range of tumorigenic cell lines and a control human fibroblast, with results indicating these organoruthenium metallocenes to possess moderate to weak cytotoxicity toward cancerous cells. | |
dc.description.peerreviewed | Yes | |
dc.description.publicationstatus | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | American Chemical Society | |
dc.publisher.place | United States | |
dc.relation.ispartofstudentpublication | N | |
dc.relation.ispartofpagefrom | 1395 | |
dc.relation.ispartofpageto | 1403 | |
dc.relation.ispartofissue | 6 | |
dc.relation.ispartofjournal | Organometallics | |
dc.relation.ispartofvolume | 30 | |
dc.rights.retention | Y | |
dc.subject.fieldofresearch | Inorganic chemistry | |
dc.subject.fieldofresearch | Biologically active molecules | |
dc.subject.fieldofresearch | Organic chemistry | |
dc.subject.fieldofresearch | Other chemical sciences | |
dc.subject.fieldofresearch | Organometallic chemistry | |
dc.subject.fieldofresearchcode | 3402 | |
dc.subject.fieldofresearchcode | 340401 | |
dc.subject.fieldofresearchcode | 3405 | |
dc.subject.fieldofresearchcode | 3499 | |
dc.subject.fieldofresearchcode | 340209 | |
dc.title | Mono- and 1,1'-Disubstituted Organoruthenium Cyclopentadiene Complexes: Synthesis, Structural Characterization, and Antitumoral Evaluation | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.rights.copyright | Self-archiving of the author-manuscript version is not yet supported by this journal. Please refer to the journal link for access to the definitive, published version or contact the author[s] for more information. | |
gro.date.issued | 2011 | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Healy, Peter C. | |