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dc.contributor.authorLevonis, Stephan M
dc.contributor.authorKiefel, Milton J
dc.contributor.authorHouston, Todd A
dc.date.accessioned2017-05-03T13:55:46Z
dc.date.available2017-05-03T13:55:46Z
dc.date.issued2011
dc.date.modified2012-02-17T05:13:33Z
dc.identifier.issn0004-9425
dc.identifier.doi10.1071/CH11296
dc.identifier.urihttp://hdl.handle.net/10072/42926
dc.description.abstractA self-assembling fluorescence sensor with boronic acid functionalities was tested for binding selectivity to the monosaccharide, sialic acid. Working from a previously reported system, a self-assembling system could form an imine in situ that enables a conjugated fluorophore to display a measurable change in fluorescence in the presence of monosaccharide. However, further examination showed that free sugars give a similar fluorescence response to just the m-aminophenylboronic acid moiety on its own. Still, such a self-assembly method may be applicable to cell surface saccharide sensing as aldehydes and ketones are noticeably absent on most cells' exteriors. The original covalent receptor appears best suited for the detection of free sialic acid.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherCSIRO Publishing
dc.publisher.placeAustralia
dc.relation.ispartofstudentpublicationY
dc.relation.ispartofpagefrom1454
dc.relation.ispartofpageto1457
dc.relation.ispartofissue11
dc.relation.ispartofjournalAustralian Journal of Chemistry
dc.relation.ispartofvolume64
dc.rights.retentionN
dc.subject.fieldofresearchChemical sciences
dc.subject.fieldofresearchOrganic chemistry not elsewhere classified
dc.subject.fieldofresearchEngineering
dc.subject.fieldofresearchcode34
dc.subject.fieldofresearchcode340599
dc.subject.fieldofresearchcode40
dc.titleComparing Self-Assembling and Covalent Fluorescent Boronolectins for the Detection of Free Sialic Acid
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyOffice of the Snr Dep Vice Chancellor, Institute for Glycomics
gro.date.issued2011
gro.hasfulltextNo Full Text
gro.griffith.authorKiefel, Milton
gro.griffith.authorHouston, Todd A.


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