Comparing Self-Assembling and Covalent Fluorescent Boronolectins for the Detection of Free Sialic Acid

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Title Comparing Self-Assembling and Covalent Fluorescent Boronolectins for the Detection of Free Sialic Acid
Author Levonis, Stephan; Kiefel, Milton; Houston, Todd Ashley
Journal Name Australian Journal of Chemistry
Year Published 2011
Place of publication Australia
Publisher CSIRO Publishing
Abstract A self-assembling fluorescence sensor with boronic acid functionalities was tested for binding selectivity to the monosaccharide, sialic acid. Working from a previously reported system, a self-assembling system could form an imine in situ that enables a conjugated fluorophore to display a measurable change in fluorescence in the presence of monosaccharide. However, further examination showed that free sugars give a similar fluorescence response to just the m-aminophenylboronic acid moiety on its own. Still, such a self-assembly method may be applicable to cell surface saccharide sensing as aldehydes and ketones are noticeably absent on most cells’ exteriors. The original covalent receptor appears best suited for the detection of free sialic acid.
Peer Reviewed Yes
Published Yes
Alternative URI http://dx.doi.org/10.1071/CH11296
Volume 64
Issue Number 11
Page from 1454
Page to 1457
ISSN 0004-9425
Date Accessioned 2012-02-06; 2012-02-17T05:13:33Z
Research Centre Institute for Glycomics
Faculty Faculty of Science, Environment, Engineering and Technology
Subject Organic Chemistry
URI http://hdl.handle.net/10072/42926
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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