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dc.contributor.authorSerre, Kevin
dc.contributor.authorSimmonds, Michael
dc.contributor.authorSabapathy, Surendran
dc.contributor.authorMinahan, Clare
dc.contributor.authorC. Gass, Gregory
dc.date.accessioned2017-05-03T13:17:44Z
dc.date.available2017-05-03T13:17:44Z
dc.date.issued2011
dc.date.modified2012-05-15T22:25:56Z
dc.identifier.issn21611017
dc.identifier.urihttp://hdl.handle.net/10072/43269
dc.description.abstractAims/hypothesis: Basal plasma concentration of asymmetric dimethylarginine (ADMA), an endogenous, competitive inhibitor of nitric oxide synthase, is elevated in patients with type 2 diabetes. ADMA may contribute to the endothelial dysfunction and associated vascular complications observed in individuals with type 2 diabetes. The present study investigated the effect of 12 weeks of supervised walking exercise on plasma ADMA concentration in women aged 65-74 years with type 2 diabetes. Materials and methods: Fourteen women (aged 69 ᠳ yrs) with uncomplicated type 2 diabetes, completed 12 weeks of supervised, moderate-intensity walking at an intensity equivalent to their individual gas-exchange threshold. Blood was sampled for ADMA concentration before and after a 6-week intervention-free control period, and again after 6 and 12 weeks of exercise training. Results: Plasma ADMA concentration was found to be significantly lower after 12-weeks of exercise training when compared with baseline (0 wk) measurements. These results were accompanied by significant increases in time to exhaustion, relative and absolute peak oxygen uptake, and oxygen uptake at gas-exchange threshold. Conclusion/interpretation: Regular, moderate-intensity exercise decreases circulating ADMA concentrations in older women with type 2 diabetes. These results suggest that ADMA may play a role in the training-induced reduction in cardiovascular disease risk seen with exercise training in individuals with type 2 Diabetes.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent1053509 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherOmics Publishing Group
dc.publisher.placeUnited States
dc.publisher.urihttp://omicsonline.org/emshome.php
dc.publisher.urihttp://www.omicsonline.org/ArchiveEMS/articleinpressEMS.php
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom001-1
dc.relation.ispartofpageto001-5
dc.relation.ispartofjournalEndocrinology & Metabolic Syndrome
dc.relation.ispartofvolumeS5
dc.rights.retentionY
dc.subject.fieldofresearchExercise Physiology
dc.subject.fieldofresearchSystems Physiology
dc.subject.fieldofresearchcode110602
dc.subject.fieldofresearchcode111603
dc.titleRapid Communication - Effect of Exercise Training on Asymmetric Dimethylarginine Concentration in Women Aged 65-74 years with Type 2 Diabetes
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.rights.copyright© The Author(s) 2011 The attached file is reproduced here in accordance with the copyright policy of the publisher. For information about this journal please refer to the journal’s website or contact the authors.
gro.date.issued2011
gro.hasfulltextFull Text
gro.griffith.authorMinahan, Clare L.
gro.griffith.authorSabapathy, Surendran
gro.griffith.authorSimmonds, Michael J.


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