Protection From Arthritis and Myositis in a Mouse Model of Acute Chikungunya Virus Disease by Bindarit, an Inhibitor of Monocyte Chemotactic Protein-1 Synthesis

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Title Protection From Arthritis and Myositis in a Mouse Model of Acute Chikungunya Virus Disease by Bindarit, an Inhibitor of Monocyte Chemotactic Protein-1 Synthesis
Author Rulli, Nestor; Rolph, Michael; Srikiatkhachorn, Anon; Anantapreecha, Surapee; Guglielmotti, Angelo; Mahalingam, Suresh
Journal Name The Journal of Infectious Diseases
Year Published 2011
Place of publication United States
Publisher Oxford University Press
Abstract Chikungunya virus (CHIKV) is associated with outbreaks of infectious rheumatic disease in humans. Using a mouse model of CHIKV arthritis and myositis, we show that tumor necrosis factor–α, interferon-γ, and monocyte chemotactic protein 1 (MCP-1) were dramatically induced in tissues from infected mice. The same factors were detected in the serum of patients with CHIKV-induced polyarthralgia and polyarthritis, with MCP-1 levels being particularly elevated. Bindarit (MCP inhibitor) treatment ameliorated CHIKV disease in mice. Histological analysis of muscle and joint tissues showed a reduction in inflammatory infiltrate in infected mice treated with bindarit. These results suggest that bindarit may be useful in treating CHIKV-induced arthritides in humans.
Peer Reviewed Yes
Published Yes
Alternative URI http://dx.doi.org/10.1093/infdis/jir470
Volume 204
Issue Number 7
Page from 1026
Page to 1030
ISSN 0022-1899
Date Accessioned 2012-03-05; 2012-03-08T22:39:31Z
Date Available 2012-03-08T22:39:31Z
Research Centre Institute for Glycomics
Faculty Faculty of Science, Environment, Engineering and Technology
Subject Medical Virology
URI http://hdl.handle.net/10072/43457
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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