A high-throughput assay for the identification of drugs against late-stage Plasmodium falciparum gametocytes
Author(s)
Peatey, Christopher L.
Spicer, Timothy P.
Hodder, Peter S.
Trenholme, Katharine R.
Gardiner, Donald
Year published
2011
Metadata
Show full item recordAbstract
Recent success in the global reduction campaign against malaria has resulted in the possibility that it may be feasible to drastically reduce or even eradicate malaria even without the introduction of a vaccine. However, while there has been significant effort to design the next generation of antimalarial drugs, one area that is underrepresented in the current antimalarial pharmacopeia is that of transmission blocking drugs directed at late-stage gametocytes. Here we describe the development of a robust and simple assay that is amenable to a high throughput format for the discovery of new antigametocyte drugs.Recent success in the global reduction campaign against malaria has resulted in the possibility that it may be feasible to drastically reduce or even eradicate malaria even without the introduction of a vaccine. However, while there has been significant effort to design the next generation of antimalarial drugs, one area that is underrepresented in the current antimalarial pharmacopeia is that of transmission blocking drugs directed at late-stage gametocytes. Here we describe the development of a robust and simple assay that is amenable to a high throughput format for the discovery of new antigametocyte drugs.
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Journal Title
Molecular and Biochemical Parasitology
Volume
180
Issue
2
Subject
Medicinal and Biomolecular Chemistry not elsewhere classified
Biological Sciences
Agricultural and Veterinary Sciences
Medical and Health Sciences