Deliberate Ignorance: A Systematic Review of Blinding in Nursing Clinical Trials

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Title Deliberate Ignorance: A Systematic Review of Blinding in Nursing Clinical Trials
Author Polit, Denise F.; Gillespie, Brigid Mary; Griffin, Ruth
Journal Name Nursing Research
Year Published 2011
Place of publication United States
Publisher Lippincott Williams & Wilkins
Abstract Background: Blinding is recommended widely as a strategy in randomized controlled trials (RCTs) to reduce biases that can result from awareness of who is receiving the intervention being tested. The absence of blinding, especially when the primary outcomes are subjective, has been found to be associated with inflated estimates of treatment effects, yet little is known about the use of blinding in nursing RCTs. Objectives: The purposes of this study were (a) to describe the extent to which nurse researchers state that they used blinding as a bias-reduction strategy or explain why it was not used, (b) to identify the groups that are blinded when blinding is used, (c) to assess whether the term blinding or masking is more prevalent, and (d) to explore factors that might affect the use or acknowledgement of blinding in nursing trials. Methods: Data regarding blinding were extracted systematically and coded from a consecutive sample of 199 RCTs published in 16 nursing journals in 2007 to 2009. Results: Blinding, the term used predominantly in nursing, was reported to have been used in 33% of the studies. Rates of blinding ranged from 2.5% for data analysts to 28% for data collectors. The absence of blinding was discussed as a limitation in only 13% of the studies in which blinding did not occur. The use or mention of blinding was related strongly to whether the journal in which the article was published had endorsed the Consolidated Standards for Reporting Trials guidelines (CONSORT). Conclusions: Nurse researchers conducting RCTs should be more diligent in following the CONSORT guidelines regarding the use and description of blinding. Although it is often impossible to blind study participants and intervention agents, the blinding of data collectors, data analysts, and nonresearch healthcare staff should be pursued.
Peer Reviewed Yes
Published Yes
Alternative URI http://dx.doi.org/10.1097/NNR.0b013e3181ff7309
Volume 60
Issue Number 1
Page from 9
Page to 16
ISSN 1538-9847
Date Accessioned 2012-03-14; 2012-04-01T23:17:14Z
Research Centre Griffith Health Institute; Centre for Health Practice Innovation
Faculty Griffith Health Faculty
Subject Nursing
URI http://hdl.handle.net/10072/44166
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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