A whole parasite vaccine to control the blood stages of Plasmodium – the case for lateral thinking

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Title A whole parasite vaccine to control the blood stages of Plasmodium – the case for lateral thinking
Author Good, Michael Francis
Journal Name Trends in Parasitology
Year Published 2011
Place of publication United Kingdom
Publisher Elsevier
Abstract Now, 27 years following the cloning of malaria antigens with the promise of the rapid development of a malaria vaccine, we face significant obstacles that are belatedly being addressed. Poor immunogenicity of subunit vaccine antigens and significant antigenic diversity of target epitopes represent major hurdles for which there are no clear strategies for a way forward within the current paradigm. Thus, a different paradigm – a vaccine that uses the whole organism – is now being examined. Although most advances in this approach relate to a vaccine for the pre-erythrocytic stages (sporozoites, liver stages), this opinion paper will outline the possibilities of developing a whole parasite vaccine for the blood stage and address some of the challenges for this strategy, which are entirely different to the challenges for a subunit vaccine. It is the view of the author that both vaccine paradigms should be pursued, but that success will come more quickly using the paranormal approach of exposing individuals to ultra-low doses of whole attenuated or killed parasites.
Peer Reviewed Yes
Published Yes
Alternative URI http://dx.doi.org/10.1016/j.pt.2011.03.003
Volume 27
Issue Number 8
Page from 335
Page to 340
ISSN 1471-4922
Date Accessioned 2012-03-07; 2012-04-03T22:44:55Z
Research Centre Institute for Glycomics
Faculty Faculty of Science, Environment, Engineering and Technology
Subject Infectious Agents
URI http://hdl.handle.net/10072/44188
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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