Efficacy and safety of a modular multi-modal exercise program in prostate cancer patients with bone metastases: A randomized controlled trial

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Title Efficacy and safety of a modular multi-modal exercise program in prostate cancer patients with bone metastases: A randomized controlled trial
Author Galvão, Daniel A; Taaffe, Dennis R; Cormie, Prue; Spry, Nigel; Chambers, Suzanne Kathleen; Peddle-McIntyre, Carolyn; Baker, Michael; Denham, James; Joseph, David; Groom, Geoff; Newton, Robert U
Journal Name BMC Cancer
Year Published 2011
Place of publication United Kingdom
Publisher BioMed Central Ltd.
Abstract Background The presence of bone metastases has excluded participation of prostate cancer patients in exercise intervention studies to date and is also a relative contraindication to supervised exercise in the community setting because of concerns of fragility fracture. However, this group of patients often have developed significant muscle atrophy and functional impairments from prior and continuing androgen deprivation that is exacerbated by subsequent and more intensive interventions such as chemotherapy. The aim of this study is to determine the efficacy and safety of a modular multi-modal exercise program in prostate cancer patients with bone metastases. Methods/Design Multi-site randomized controlled trial in Western Australia and New South Wales to examine the efficacy and safety of a modular multi-modal physical exercise program in 90 prostate cancer survivors with bone metastases. Participants will be randomized to (1) modular multi-modal exercise intervention group or (2) usual medical care group. The modular multi-modal exercise group will receive a 3-month supervised exercise program based on bone lesion location/extent. Measurements for primary and secondary endpoints will take place at baseline, 3 months (end of the intervention) and 6 months follow-up. Discussion Delaying or preventing skeletal complication and improving physical function for men with bone metastases would provide clinically meaningful benefits to patients. However, exercise programs must be designed and executed with careful consideration of the skeletal complications associated with bone metastatic disease and cumulative toxicities from androgen deprivation such as osteoporosis and increased risk of fractures. The results from this study will form the basis for the development of a specific exercise prescription in this patient group in order to alleviate disease burden, counteract the adverse treatment related side-effects and enhance quality of life.
Peer Reviewed Yes
Published Yes
Alternative URI http://dx.doi.org/10.1186/1471-2407-11-517
Copyright Statement Copyright 2011, http://dx.doi.org/10.1186/1471-2407-11-517 et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Volume 11
Page from 517-1
Page to 517-7
ISSN 1471-2407
Date Accessioned 2011-12-14; 2012-04-03T22:51:58Z
Research Centre Behavioural Basis of Health; Centre for Health Practice Innovation
Faculty Griffith Health Faculty
Subject Human Movement and Sports Science
URI http://hdl.handle.net/10072/44198
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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