Our impasse in developing a malaria vaccine

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Title Our impasse in developing a malaria vaccine
Author Good, Michael Francis
Journal Name Cellular and Molecular Life Sciences
Year Published 2011
Place of publication Switzerland
Publisher Springer
Abstract Malaria presents a challenge to world health that to date has been beyond the abilities of researchers to conquer. This critique presents some of the strategies employed by the parasite to overcome immunity and the immunological challenges that we face to develop vaccines. A conclusion is that a vaccine must identify novel antigens or epitopes that are not normally immunogenic and which are therefore not under immune pressure and most likely to be conserved between different strains. Such antigens are most likely to be targets of cellular immunity. The case for a whole parasite blood stage vaccine is presented based on these premises.
Peer Reviewed Yes
Published Yes
Alternative URI http://dx.doi.org/10.1007/s00018-011-0634-5
Volume 68
Issue Number 7
Page from 1105
Page to 1113
ISSN 1420-682X
Date Accessioned 2012-03-07; 2012-04-09T23:09:37Z
Date Available 2012-04-09T23:09:37Z
Research Centre Institute for Glycomics
Faculty Faculty of Science, Environment, Engineering and Technology
Subject Infectious Agents
URI http://hdl.handle.net/10072/44307
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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