The sap from Euphorbia peplus is effective against human nonmelanoma skin cancers

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Title The sap from Euphorbia peplus is effective against human nonmelanoma skin cancers
Author Ramsay, James; Suhrbier, Andreas; Aylward, J. H.; Ogbourne, S.; S, -J Cozzi; Poulsen, M. G.; Baumann, K. C.; Welburn, P.; Redlich, G. L.; Parsons, Peter Gordon
Journal Name British Journal of Dermatology
Year Published 2011
Place of publication United Kingdom
Publisher Wiley-Blackwell Publishing Ltd
Abstract Background The sap from Euphorbia peplus, commonly known as petty spurge in the U.K. or radium weed in Australia, has been used as a traditional treatment for a number of cancers. Objective To determine the effectiveness of E. peplus sap in a phase I ⁄II clinical study for the topical treatment of basal cell carcinomas (BCC), squamous cell carcinomas (SCC) and intraepidermal carcinomas (IEC). Methods Thirty-six patients, who had refused, failed or were unsuitable for conventional treatment, were enrolled in a phase I ⁄II clinical study. A total of 48 skin cancer lesions were treated topically with 100–300 lL of E. peplus sap once daily for 3 days. Results The complete clinical response rates at 1 month were 82% (n = 28) for BCC, 94% (n = 16) for IEC and 75% (n = 4) for SCC. After a mean follow-up of 15 months these rates were 57%, 75% and 50%, respectively. For superficial lesions < 16 mm, the response rates after follow-up were 100% for IEC (n = 10) and 78% for BCC (n = 9). Conclusions The clinical responses for these relatively unfavourable lesions (43% had failed previous treatments, 35% were situated in the head and neck region and 30% were > 2 cm in diameter), are comparable with existing nonsurgical treatments. An active ingredient of E. peplus sap has been identified as ingenol mebutate (PEP005). This clinical study affirms community experience with E. peplus sap, and supports further clinical development of PEP005 for the treatment of BCC, SCC and IEC.
Peer Reviewed Yes
Published Yes
Alternative URI http://dx.doi.org/10.1111/j.1365-2133.2010.10184.x
Volume 164
Issue Number 3
Page from 633
Page to 636
ISSN 0007-0963
Date Accessioned 2012-03-21; 2012-04-09T23:13:44Z
Date Available 2012-04-09T23:13:44Z
Faculty Griffith Health Faculty
Subject Clinical Sciences
URI http://hdl.handle.net/10072/44313
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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