Fabrication of high surface area mesoporous silicon via magnesiothermic reduction for drug delivery

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Title Fabrication of high surface area mesoporous silicon via magnesiothermic reduction for drug delivery
Author Guo, Mingyi; Zou, Xiaoqin; Ren, Hao; Muhammad, Faheem; Huang, Caixia; Qiu, Shilun; Zhu, Guangshan
Journal Name Microporous and Mesoporous Materials
Year Published 2011
Place of publication Netherlands
Publisher Elsevier
Abstract In this study, mesoporous silicon was achieved from ordered mesoporous silica via magnesiothermic reduction reaction, while preserving the original shape, mesoporous structure as well as high surface area. Rod-like SBA-15 with hexagonal array of 2D channels and crystal-like SBA-16 with body centered arrangement of cages were used as precursors, suitable wall thickness and mesoporous structures facilitated the formation of products with high porosity and the preservation of original morphologies. X-ray diffraction (XRD), selected area electron diffraction (SAED), energy dispersive X-ray spectroscopy (EDS) and Raman spectra revealed that high crystallinity and purity of the resulted products were obtained. N2 sorption isotherm results showed that the mesoporous silicon derived from hexagonal SBA-15 has much higher surface area than that from cubic SBA-16, which is reasonably attributed to the difference of wall thickness and porous structures of the precursors. High surface area Si-SBA-15 was selected as vector and ibuprofen as a model drug for drug release, and the system displayed superior drug loading and good release profile.
Peer Reviewed Yes
Published Yes
Alternative URI http://dx.doi.org/10.1016/j.micromeso.2010.11.036
Volume 142
Issue Number 1
Page from 194
Page to 201
ISSN 1387-1811
Date Accessioned 2012-02-18; 2012-04-10T22:55:59Z
Research Centre Queensland Micro and Nanotechnology Centre
Faculty Faculty of Science, Environment, Engineering and Technology
Subject Inorganic Chemistry
URI http://hdl.handle.net/10072/44381
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1x

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