Arthrogenic Alphaviruses and Inflammatory Myopathies

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Title Arthrogenic Alphaviruses and Inflammatory Myopathies
Author Herrero, Lara; Mahalingam, Suresh
Book Title Idiopathic Inflammatory Myopathies – Recent Developments
Year Published 2011
Place of publication Croatia
Publisher In tech
Abstract There is increasing evidence to suggest that viruses have aetiological roles in the idiopathic inflammatory myopathies. Arthrogenic alphaviruses (such as chikungunya virus, Ross River virus and sindbis virus) are known to cause outbreaks of polyarthritis worldwide. The clinical presentation of alphavirus infection includes fever, rash, arthralgia, and arthritis, however, one of the most predominant features of alphaviral disease are symptoms of myalgia with corresponding myositis. The recent outbreaks of chikungunya virus in several countries surrounding the Indian Ocean has seen millions of people affected, with case reports indicating a high incidence of myalgia and skeletal muscle involvement in the aetiology of this disease. The mechanisms of how alphaviruses cause musculoskeletal disease are slowly being unraveled with evidence to suggest that the viral induced inflammation can result in damage to the skeletal muscle tissues, possibly explaining the symptoms of myalgia. In recent years, the use of small animal models for alphavirus-induced myositis has furthered our understanding of the idiopathic inflammatory myopathies caused by these viruses. This chapter will discuss the role of alphaviruses as an often-overlooked cause of myositis, including how small animal models are being used to dissect the pathobiology of disease and identify potential drug candidates to ameliorate disease.
Peer Reviewed Yes
Published Yes
Alternative URI
Chapter Number 3
Page from 43
Page to 64
ISBN 9789533076942
Date Accessioned 2012-03-30; 2012-04-17T22:27:35Z
Research Centre Institute for Glycomics
Faculty Faculty of Science, Environment, Engineering and Technology
Subject Virology
Publication Type Book Chapters
Publication Type Code b1

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