Novel bacterial MerR-like regulators: their role in the response to carbonyl and nitrosative stress

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Title Novel bacterial MerR-like regulators: their role in the response to carbonyl and nitrosative stress
Author McEwan, Alastair G.; Djoko, Karrera Y.; Chen, Nathan H.; Counago, Rafael L.M.; Kidd, Stephen P.; Potter, Adam J.; Jennings, Michael Paul
Book Title Advances in Microbial Physiology
Editor Robert K Poole
Year Published 2011
Place of publication United Kingdom
Publisher Elsevier
Abstract Recognition of the diversity of transcriptional regulators of the MerR family has increased considerably over the last decade and it has been established that not all MerR-like regulators are involved in metal ion recognition. A new type of MerR-like regulator was identified in Neisseria gonorrhoeae that is distinct from metal-binding MerR proteins. This novel transcription factor, the Neisseria merR-like regulator (NmlR) is related to a large and diverse group of MerR-like regulators. A common feature of the majority of the genes encoding the nmlR-related genes is that they predicted to control the expression of adhC, which encodes a glutathione-dependent alcohol dehydrogenase. The function of the NmlR regulon appears to be to defend the bacterial cell against carbonyl stress and in some cases nitrosative stress. A potential role for NmlR in bacterial pathogenesis has been identified in Neisseria gonorrhoeae and Streptococcus pneumoniae. Although it is not known how NmlR is activated it is suggested that conserved cysteine residues may be involved in thiol-based signaling.
Peer Reviewed Yes
Published Yes
Alternative URI
Copyright Statement Self-archiving is not yet supported by this publisher. Please refer to the publisher's website or contact the author(s) for more information.
Volume 58
Chapter Number 1
Page from 1
Page to 22
ISBN 9780123810434
Date Accessioned 2012-03-22; 2012-04-22T22:19:04Z
Research Centre Institute for Glycomics
Faculty Faculty of Science, Environment, Engineering and Technology
Subject Medical Microbiology
Publication Type Book Chapters
Publication Type Code b1

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