Rodent blood-stage Plasmodium survive in dendritic cells that infect naive mice

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Title Rodent blood-stage Plasmodium survive in dendritic cells that infect naive mice
Author Wykes, Michelle N.; Kay, Jason G.; Manderson, Anthony; Liu, Xueqin; Brown, Darren L.; Richard, Derek J.; Wipasa, Jiraprapa; Jiang, Suhua H.; Jones, Malcolm K.; Janse, Chris J.; Waters, Andrew P.; Pierce, Susan K.; Miller, Louis H.; Stow, Jennifer L.; Good, Michael Francis
Journal Name Proceedings of the National Academy of Sciences
Year Published 2011
Place of publication United States
Publisher National Academy of Sciences
Abstract Plasmodium spp. parasites cause malaria in 300 to 500 million individuals each year. Disease occurs during the blood-stage of the parasite's life cycle, where the parasite is thought to replicate exclusively within erythrocytes. Infected individuals can also suffer relapses after several years, from Plasmodium vivax and Plasmodium ovale surviving in hepatocytes. Plasmodium falciparum and Plasmodium malariae can also persist after the original bout of infection has apparently cleared in the blood, suggesting that host cells other than erythrocytes (but not hepatocytes) may harbor these blood-stage parasites, thereby assisting their escape from host immunity. Using blood stage transgenic Plasmodium berghei-expressing GFP (PbGFP) to track parasites in host cells, we found that the parasite had a tropism for CD317+ dendritic cells. Other studies using confocal microscopy, in vitro cultures, and cell transfer studies showed that blood-stage parasites could infect, survive, and replicate within CD317+ dendritic cells, and that small numbers of these cells released parasites infectious for erythrocytes in vivo. These data have identified a unique survival strategy for blood-stage Plasmodium, which has significant implications for understanding the escape of Plasmodium spp. from immune-surveillance and for vaccine development.
Peer Reviewed Yes
Published Yes
Alternative URI http://dx.doi.org/10.1073/pnas.1108579108
Volume 108
Issue Number 27
Page from 11205
Page to 11210
ISSN 0027-8424
Date Accessioned 2012-03-07; 2012-04-23T21:56:21Z
Date Available 2012-04-23T21:56:21Z
Research Centre Institute for Glycomics
Faculty Faculty of Science, Environment, Engineering and Technology
Subject Infectious Agents
URI http://hdl.handle.net/10072/44612
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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