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dc.contributor.authorDu, Zhibin
dc.contributor.authorChen, Jiang
dc.contributor.authorYan, Fuhua
dc.contributor.authorDoan, Nghiem
dc.contributor.authorIvanovski, Saso
dc.contributor.authorXiao, Yin
dc.date.accessioned2018-06-15T02:11:31Z
dc.date.available2018-06-15T02:11:31Z
dc.date.issued2013
dc.date.modified2014-08-28T05:05:53Z
dc.identifier.issn0905-7161
dc.identifier.doi10.1111/j.1600-0501.2011.02341.x
dc.identifier.urihttp://hdl.handle.net/10072/44704
dc.description.abstractObjective: Simvastatin has been shown to enhance osseointegration of pure titanium implants in osteoporotic rats. This study aimed to evaluate the relationship between the serum level of bone formation markers and the osseointegration of pure titanium implants in osteoporotic rats treated with simvastatin. Materials and methods: Fifty-four female Sprague-Dawley rats, aged 3 months, were randomly divided into three groups: Sham-operated group (SHAM; n = 18), ovariectomized group (OVX; n = 18), and ovariectomized with simvastatin treatment group (OVX + SIM; n = 18). Fifty-six days after ovariectomy, screw-shaped titanium implants were inserted into the tibiae. Simvastatin was administered orally at 5 mg/kg each day after the placement of the implant in the OVX + SIM group. The animals were killed at either 28 or 84 days after implantation and the undecalcified tissue sections were processed for histological analysis. Total alkaline phosphatase (ALP), bonespecific alkaline phosphatase (BALP) and bone Gla protein (BGP) were measured in all animal sera collected at the time of euthanasia and correlated with the histological assessment of osseointegration. Results: The level of ALP in the OVX group was higher than the SHAM group at day 28, with no differences between the three groups at day 84. The level of BALP in the OVX + SIM group was significantly higher than both OVX and SHAM groups at days 28. Compared with day 28, the BALP level of all three groups showed a significant decrease at day 84. There were no significant differences in BGP levels between the three groups at day 28, but at day 84, the OVX + SIM group showed significantly higher levels than both the OVX and SHAM groups. There was a significant increase in BGP levels between days 28 and 84 in the OVX + SIM group. The serum bone marker levels correlated with the histological assessment showing reduced osseointegration in the OVX compared to the SHAM group which is subsequently reversed in the OVX + SIM group. Conclusion: The results from this study indicate that the serum level of bone formation markers, especially BALP and BGP, could be correlated with the degree of osseointegration around titanium implants in osteoporotic rats treated with simvastatin.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherWiley-Blackwell Publishing
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom422
dc.relation.ispartofpageto427
dc.relation.ispartofissue4
dc.relation.ispartofjournalClinical Oral Implants Research
dc.relation.ispartofvolume24
dc.rights.retentionY
dc.subject.fieldofresearchBiomedical engineering
dc.subject.fieldofresearchBiomedical engineering not elsewhere classified
dc.subject.fieldofresearchDentistry
dc.subject.fieldofresearchcode4003
dc.subject.fieldofresearchcode400399
dc.subject.fieldofresearchcode3203
dc.titleSerum bone formation marker correlation with improved osseointegration in osteoporotic rats treated with simvastatin
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dc.description.versionAccepted Manuscript (AM)
gro.rights.copyright© 2013 John Wiley & Sons A/S. This is the peer reviewed version of the following article: Serum bone formation marker correlation with improved osseointegration in osteoporotic rats treated with simvastatin, Clinical Oral Implants Research, Volume 24, Issue 4, Pages 422-427, 2013, which has been published in final form at https://doi.org/10.1111/j.1600-0501.2011.02341.x. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving (http://olabout.wiley.com/WileyCDA/Section/id-828039.html)
gro.date.issued2013
gro.hasfulltextFull Text
gro.griffith.authorXiao, Yin


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