dc.contributor.author | Du, Zhibin | |
dc.contributor.author | Chen, Jiang | |
dc.contributor.author | Yan, Fuhua | |
dc.contributor.author | Doan, Nghiem | |
dc.contributor.author | Ivanovski, Saso | |
dc.contributor.author | Xiao, Yin | |
dc.date.accessioned | 2018-06-15T02:11:31Z | |
dc.date.available | 2018-06-15T02:11:31Z | |
dc.date.issued | 2013 | |
dc.date.modified | 2014-08-28T05:05:53Z | |
dc.identifier.issn | 0905-7161 | |
dc.identifier.doi | 10.1111/j.1600-0501.2011.02341.x | |
dc.identifier.uri | http://hdl.handle.net/10072/44704 | |
dc.description.abstract | Objective: Simvastatin has been shown to enhance osseointegration of pure titanium implants in
osteoporotic rats. This study aimed to evaluate the relationship between the serum level of bone
formation markers and the osseointegration of pure titanium implants in osteoporotic rats treated
with simvastatin.
Materials and methods: Fifty-four female Sprague-Dawley rats, aged 3 months, were randomly
divided into three groups: Sham-operated group (SHAM; n = 18), ovariectomized group (OVX;
n = 18), and ovariectomized with simvastatin treatment group (OVX + SIM; n = 18). Fifty-six days
after ovariectomy, screw-shaped titanium implants were inserted into the tibiae. Simvastatin was
administered orally at 5 mg/kg each day after the placement of the implant in the OVX + SIM
group. The animals were killed at either 28 or 84 days after implantation and the undecalcified
tissue sections were processed for histological analysis. Total alkaline phosphatase (ALP), bonespecific
alkaline phosphatase (BALP) and bone Gla protein (BGP) were measured in all animal sera
collected at the time of euthanasia and correlated with the histological assessment of
osseointegration.
Results: The level of ALP in the OVX group was higher than the SHAM group at day 28, with no
differences between the three groups at day 84. The level of BALP in the OVX + SIM group was
significantly higher than both OVX and SHAM groups at days 28. Compared with day 28, the BALP
level of all three groups showed a significant decrease at day 84. There were no significant
differences in BGP levels between the three groups at day 28, but at day 84, the OVX + SIM group
showed significantly higher levels than both the OVX and SHAM groups. There was a significant
increase in BGP levels between days 28 and 84 in the OVX + SIM group. The serum bone marker
levels correlated with the histological assessment showing reduced osseointegration in the OVX
compared to the SHAM group which is subsequently reversed in the OVX + SIM group.
Conclusion: The results from this study indicate that the serum level of bone formation markers,
especially BALP and BGP, could be correlated with the degree of osseointegration around titanium
implants in osteoporotic rats treated with simvastatin. | |
dc.description.peerreviewed | Yes | |
dc.description.publicationstatus | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Wiley-Blackwell Publishing | |
dc.publisher.place | United States | |
dc.relation.ispartofstudentpublication | N | |
dc.relation.ispartofpagefrom | 422 | |
dc.relation.ispartofpageto | 427 | |
dc.relation.ispartofissue | 4 | |
dc.relation.ispartofjournal | Clinical Oral Implants Research | |
dc.relation.ispartofvolume | 24 | |
dc.rights.retention | Y | |
dc.subject.fieldofresearch | Biomedical engineering | |
dc.subject.fieldofresearch | Biomedical engineering not elsewhere classified | |
dc.subject.fieldofresearch | Dentistry | |
dc.subject.fieldofresearchcode | 4003 | |
dc.subject.fieldofresearchcode | 400399 | |
dc.subject.fieldofresearchcode | 3203 | |
dc.title | Serum bone formation marker correlation with improved osseointegration in osteoporotic rats treated with simvastatin | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
dc.description.version | Accepted Manuscript (AM) | |
gro.rights.copyright | © 2013 John Wiley & Sons A/S. This is the peer reviewed version of the following article: Serum bone formation marker correlation with improved osseointegration in osteoporotic rats treated with simvastatin, Clinical Oral Implants Research, Volume 24, Issue 4, Pages 422-427, 2013, which has been published in final form at https://doi.org/10.1111/j.1600-0501.2011.02341.x. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving (http://olabout.wiley.com/WileyCDA/Section/id-828039.html) | |
gro.date.issued | 2013 | |
gro.hasfulltext | Full Text | |
gro.griffith.author | Xiao, Yin | |