Single Nucleotide Polymorphism in hsa-mir-196a-2 and Breast Cancer Risk: A Case Control Study

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Title Single Nucleotide Polymorphism in hsa-mir-196a-2 and Breast Cancer Risk: A Case Control Study
Author Jedlinski, Dominik; Gabrovska, Pam; Weinstein, Stephen Rudolph; Smith, Robert Anthony; Griffiths, Lyn
Journal Name Twin Research and Human Genetics
Year Published 2011
Place of publication United Kingdom
Publisher Cambridge University Press
Abstract microRNAs are small, non-coding RNAs that influence gene expression on a post-transcriptional level. They participate in diverse biological pathways and may act as either tumor suppressor genes or oncogenes. As they may have an effect on thousands of target mRNAs, single-nucleotide polymorphisms in microRNA genes might have major functional consequences, because the microRNA’s properties and/or maturation may change. miR-196a has been reported to be aberrantly expressed in breast cancer tissue. Additionally, the SNP rs11614913 in hsa-mir-196a-2 has been found to be associated with breast cancer risk in some studies although not in others. This study evaluated the association between rs11614913 and breast cancer risk in a Caucasian case-control cohort in Queensland, Australia. Results do not support an association of the tested hsa-mir-196a-2 polymorphism with breast cancer susceptibility in this cohort. As there is a discrepancy between our results and previous findings, it is important to assess the role of rs11614913 in breast cancer by further larger studies investigating different ethnic groups.
Peer Reviewed Yes
Published Yes
Alternative URI http://dx.doi.org/10.1375/twin.14.5.417
Copyright Statement Copyright 2011 Cambridge University Press. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
Volume 14
Issue Number 5
Page from 417
Page to 421
ISSN 1832-4274
Date Accessioned 2012-04-12
Language en_US
Research Centre Griffith Health Institute; Molecular Basis of Disease
Faculty Griffith Health Faculty
Subject Genome Structure and Regulation
URI http://hdl.handle.net/10072/44724
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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