Cytotoxic Evaluation of Alkaloids and Isoflavonoids from the Australian Tree Erythrina vespertilio
Author(s)
Iranshahi, Mehrdad
Hoan, Vu
Ngoc, Pham
Zencak, Dusan
Forster, Paul
Quinn, Ronald J
Griffith University Author(s)
Year published
2012
Metadata
Show full item recordAbstract
A new glucoalkaloid, vespertilioside, together with three known alkaloids, including 11-߭methoxyglucoerysovine, erysotrine, and hypaphorine, were isolated from the fruits of E. vespertilio Benth. In addition, three known isoflavonoids, including phaseollin, alpiniumisoflavone, and phaseollidin, were identified from the plant stems. The structures of compounds were determined by 1D/2D NMR and mass experiments. The cytotoxic activity of all compounds was evaluated against a metastatic prostate cancer cell line (PC3) and neonatal foreskin fibroblast (NFF) using a real-time label-free cell analyser. Among the tested compounds, ...
View more >A new glucoalkaloid, vespertilioside, together with three known alkaloids, including 11-߭methoxyglucoerysovine, erysotrine, and hypaphorine, were isolated from the fruits of E. vespertilio Benth. In addition, three known isoflavonoids, including phaseollin, alpiniumisoflavone, and phaseollidin, were identified from the plant stems. The structures of compounds were determined by 1D/2D NMR and mass experiments. The cytotoxic activity of all compounds was evaluated against a metastatic prostate cancer cell line (PC3) and neonatal foreskin fibroblast (NFF) using a real-time label-free cell analyser. Among the tested compounds, phaseollidin showed cytotoxic activities against PC3 (IC50 = 8.83 ᠱ.87 卩 and NFF (0.64 ᠰ.37 卩 cell lines.
View less >
View more >A new glucoalkaloid, vespertilioside, together with three known alkaloids, including 11-߭methoxyglucoerysovine, erysotrine, and hypaphorine, were isolated from the fruits of E. vespertilio Benth. In addition, three known isoflavonoids, including phaseollin, alpiniumisoflavone, and phaseollidin, were identified from the plant stems. The structures of compounds were determined by 1D/2D NMR and mass experiments. The cytotoxic activity of all compounds was evaluated against a metastatic prostate cancer cell line (PC3) and neonatal foreskin fibroblast (NFF) using a real-time label-free cell analyser. Among the tested compounds, phaseollidin showed cytotoxic activities against PC3 (IC50 = 8.83 ᠱ.87 卩 and NFF (0.64 ᠰ.37 卩 cell lines.
View less >
Journal Title
Planta Medica: natural products and medicinal plant research
Volume
78
Issue
7
Subject
Biologically active molecules
Plant biology
Traditional, complementary and integrative medicine
Pharmacology and pharmaceutical sciences