Long-Term Intermittent Multiple Micronutrient Supplementation Enhances Hemoglobin and Micronutrient Status More Than Iron plus Folic Acid Supplementation in Bangladeshi Rural Adolescent Girls with Nutritional Anemia

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Title Long-Term Intermittent Multiple Micronutrient Supplementation Enhances Hemoglobin and Micronutrient Status More Than Iron plus Folic Acid Supplementation in Bangladeshi Rural Adolescent Girls with Nutritional Anemia
Author Ahmed, Faruk; Khan, Moududur R.; Akhtaruzzaman, Mohammad; Karim, Rezaul; Williams, Gail; Torlesse, Harriet; Darnton-Hill, Ian; Dalmiya, Nita; Banu, Cadi P.; Nahar, Badrun
Journal Name The Journal of Nutrition
Year Published 2010
Place of publication United States
Publisher American Society for Nutrition
Abstract Previous short-term supplementation studies showed no additional hematologic benefit of multiple micronutrients (MMN) compared with iron + folic acid (IFA) in adolescent girls. This study examines whether long-term once- or twice-weekly supplementation of MMN can improve hemoglobin (Hb) and micronutrient status more than twice-weekly IFA supplementation in anemic adolescent girls in Bangladesh. Anemic girls (n = 324) aged 11–17 y attending rural schools were given once- or twice-weekly MMN or twice-weekly IFA, containing 60 mg iron/dose in both supplements, for 52 wk in a randomized double-blind trial. Blood samples were collected at baseline and 26 and 52 wk. Intent to treat analysis showed no significant difference in the Hb concentration between treatments at either 26 or 52 wk. However, after excluding girls with hemoglobinopathy and adjustment for baseline Hb, a greater increase in Hb was observed with twice-weekly MMN at 26 wk (P = 0.045). Although all 3 treatments effectively reduced iron deficiency, once-weekly MMN produced significantly lower serum ferritin concentrations than the other treatments at both 26 and 52 wk. Both once- and twice-weekly MMN significantly improved riboflavin, vitamin A, and vitamin C status compared with IFA. Overall, once-weekly MMN was less efficacious than twice-weekly MMN in improving iron, riboflavin, RBC folic acid, and vitamin A levels. Micronutrient supplementation beyond 26 wk was likely important in sustaining improved micronutrient status. These findings highlight the potential usefulness of MMN intervention in this population and have implications for programming.
Peer Reviewed Yes
Published Yes
Publisher URI http://jn.nutrition.org/content/140/10/1879.abstract
Alternative URI http://dx.doi.org/10.3945/jn.109.119123
Volume 140
Issue Number 10
Page from 1879
Page to 1886
ISSN 0022-3166
Date Accessioned 2012-03-20
Date Available 2012-06-07T22:10:23Z
Language en_US
Research Centre Centre for Health Practice Innovation
Faculty Griffith Health Faculty
Subject Nutrition and Dietetics
URI http://hdl.handle.net/10072/44874
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1x

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