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dc.contributor.authorBaba, H
dc.contributor.authorNimmo, GR
dc.contributor.authorAllworth, AM
dc.contributor.authorBoots, RJ
dc.contributor.authorHayashi, Y
dc.contributor.authorLipman, J
dc.contributor.authorPaterson, DL
dc.date.accessioned2017-05-03T14:20:06Z
dc.date.available2017-05-03T14:20:06Z
dc.date.issued2011
dc.date.modified2012-05-29T22:47:18Z
dc.identifier.issn0934-9723
dc.identifier.doi10.1007/s10096-010-1146-1
dc.identifier.urihttp://hdl.handle.net/10072/44885
dc.description.abstractSurveillance cultures may detect colonisation with drug-resistant Gram-negative bacteria and can be hypothesised to guide appropriate initial antibiotic treatment for intensive care unit (ICU) patients. We investigated the microbiological data of 228 episodes of nosocomial bloodstream infection (BSI) due to Gram-negative bacteria in an ICU in which piperacillin/tazobactam or meropenem was used empirically for serious infections, to evaluate the contribution of surveillance cultures to an appropriate choice of initial antibiotic therapy. Surveillance cultures were taken in advance of BSI in 218 (95.6%) of 228 episodes. Concordant organisms with identical identification and susceptibilities were found in prior surveillance cultures and subsequent blood cultures in 65 (29.8%) of 218 episodes. Surveillance cultures predicted resistance in 52.9% and 51.4% of BSIs caused by resistant pathogens to piperacillin/tazobactam and meropenem, respectively. The negative predictive value of surveillance cultures negative for a resistant organism also exceeded 90% for piperacillin/tazobactam and meropenem. Given that the overall resistant rates of BSI pathogens of our study were 11.3% to piperacillin/tazobactam and 16.4% to meropenem, surveillance cultures in our setting may provide important information on the probability of drug resistance of the causative pathogens and some utility in aiding empiric antibiotic therapy for ICU patients who subsequently develop BSI.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherSpringer
dc.publisher.placeGermany
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom739
dc.relation.ispartofpageto744
dc.relation.ispartofissue6
dc.relation.ispartofjournalEuropean Journal of Clinical Microbiology & Infectious Diseases
dc.relation.ispartofvolume30
dc.rights.retentionY
dc.subject.fieldofresearchBiological sciences
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.subject.fieldofresearchcode31
dc.subject.fieldofresearchcode32
dc.titleThe role of surveillance cultures in the prediction of susceptibility patterns of Gram-negative bacilli in the intensive care unit
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2011
gro.hasfulltextNo Full Text
gro.griffith.authorNimmo, Graeme R.


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