dc.contributor.author | Zalucki, Yaramah M | |
dc.contributor.author | Beacham, Ifor R | |
dc.contributor.author | Jennings, Michael P | |
dc.date.accessioned | 2017-05-03T11:17:36Z | |
dc.date.available | 2017-05-03T11:17:36Z | |
dc.date.issued | 2011 | |
dc.date.modified | 2012-05-31T21:51:08Z | |
dc.identifier.issn | 1860-6768 | |
dc.identifier.doi | 10.1002/biot.201000334 | |
dc.identifier.uri | http://hdl.handle.net/10072/45323 | |
dc.description.abstract | Proteins destined for export via the Sec-dependent pathway are synthesized with a short N-terminal signal peptide. A requirement for export is that the proteins are in a translocationally competent state. This is a loosely folded state that allows the protein to pass through the SecYEG apparatus and pass into the periplasm. In order to maintain pre-secretory proteins in an export-competent state, there are many factors that slow the folding of the pre-secretory protein in the cytoplasm. These include cytoplasmic chaperones, such as SecB, and the signal recognition particle, which bind the pre-secretory protein and direct it to the cytoplasmic membrane for export. Recently, evidence has been published that non-optimal codons in the signal sequence are important for a time-critical early event to allow the correct folding of pre-secretory proteins. This review details the recent developments in folding of the signal peptide and the pre-secretory protein. | |
dc.description.peerreviewed | Yes | |
dc.description.publicationstatus | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Wiley - VCH Verlag GmbH & Co. KGaA | |
dc.publisher.place | Germany | |
dc.relation.ispartofstudentpublication | N | |
dc.relation.ispartofpagefrom | 660 | |
dc.relation.ispartofpageto | 667 | |
dc.relation.ispartofissue | 6 | |
dc.relation.ispartofjournal | Biotechnology Journal | |
dc.relation.ispartofvolume | 6 | |
dc.rights.retention | Y | |
dc.subject.fieldofresearch | Environmental biotechnology | |
dc.subject.fieldofresearch | Industrial biotechnology | |
dc.subject.fieldofresearch | Medical biotechnology | |
dc.subject.fieldofresearch | Medical microbiology not elsewhere classified | |
dc.subject.fieldofresearch | Biochemistry and cell biology | |
dc.subject.fieldofresearchcode | 4103 | |
dc.subject.fieldofresearchcode | 3106 | |
dc.subject.fieldofresearchcode | 3206 | |
dc.subject.fieldofresearchcode | 320799 | |
dc.subject.fieldofresearchcode | 3101 | |
dc.title | Coupling between codon usage, translation and protein export in Escherichia coli | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.date.issued | 2011 | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Beacham, Ifor R. | |
gro.griffith.author | Jennings, Michael P. | |
gro.griffith.author | Zalucki, Yaramah | |