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dc.contributor.authorZalucki, Yaramah M
dc.contributor.authorBeacham, Ifor R
dc.contributor.authorJennings, Michael P
dc.date.accessioned2017-05-03T11:17:36Z
dc.date.available2017-05-03T11:17:36Z
dc.date.issued2011
dc.date.modified2012-05-31T21:51:08Z
dc.identifier.issn1860-6768
dc.identifier.doi10.1002/biot.201000334
dc.identifier.urihttp://hdl.handle.net/10072/45323
dc.description.abstractProteins destined for export via the Sec-dependent pathway are synthesized with a short N-terminal signal peptide. A requirement for export is that the proteins are in a translocationally competent state. This is a loosely folded state that allows the protein to pass through the SecYEG apparatus and pass into the periplasm. In order to maintain pre-secretory proteins in an export-competent state, there are many factors that slow the folding of the pre-secretory protein in the cytoplasm. These include cytoplasmic chaperones, such as SecB, and the signal recognition particle, which bind the pre-secretory protein and direct it to the cytoplasmic membrane for export. Recently, evidence has been published that non-optimal codons in the signal sequence are important for a time-critical early event to allow the correct folding of pre-secretory proteins. This review details the recent developments in folding of the signal peptide and the pre-secretory protein.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherWiley - VCH Verlag GmbH & Co. KGaA
dc.publisher.placeGermany
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom660
dc.relation.ispartofpageto667
dc.relation.ispartofissue6
dc.relation.ispartofjournalBiotechnology Journal
dc.relation.ispartofvolume6
dc.rights.retentionY
dc.subject.fieldofresearchEnvironmental biotechnology
dc.subject.fieldofresearchIndustrial biotechnology
dc.subject.fieldofresearchMedical biotechnology
dc.subject.fieldofresearchMedical microbiology not elsewhere classified
dc.subject.fieldofresearchBiochemistry and cell biology
dc.subject.fieldofresearchcode4103
dc.subject.fieldofresearchcode3106
dc.subject.fieldofresearchcode3206
dc.subject.fieldofresearchcode320799
dc.subject.fieldofresearchcode3101
dc.titleCoupling between codon usage, translation and protein export in Escherichia coli
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2011
gro.hasfulltextNo Full Text
gro.griffith.authorBeacham, Ifor R.
gro.griffith.authorJennings, Michael P.
gro.griffith.authorZalucki, Yaramah


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