Coupling between codon usage, translation and protein export in Escherichia coli

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Title Coupling between codon usage, translation and protein export in Escherichia coli
Author Zalucki, Yaramah M.; Beacham, Ifor Rhys; Jennings, Michael Paul
Journal Name Biotechnology Journal
Year Published 2011
Place of publication Germany
Publisher Wiley - VCH Verlag GmbH & Co. KGaA
Abstract Proteins destined for export via the Sec-dependent pathway are synthesized with a short N-terminal signal peptide. A requirement for export is that the proteins are in a translocationally competent state. This is a loosely folded state that allows the protein to pass through the SecYEG apparatus and pass into the periplasm. In order to maintain pre-secretory proteins in an export-competent state, there are many factors that slow the folding of the pre-secretory protein in the cytoplasm. These include cytoplasmic chaperones, such as SecB, and the signal recognition particle, which bind the pre-secretory protein and direct it to the cytoplasmic membrane for export. Recently, evidence has been published that non-optimal codons in the signal sequence are important for a time-critical early event to allow the correct folding of pre-secretory proteins. This review details the recent developments in folding of the signal peptide and the pre-secretory protein.
Peer Reviewed Yes
Published Yes
Alternative URI
Volume 6
Issue Number 6
Page from 660
Page to 667
ISSN 1860-6768
Date Accessioned 2012-03-22; 2012-05-31T21:51:08Z
Research Centre Institute for Glycomics
Faculty Faculty of Science, Environment, Engineering and Technology
Subject Medical Microbiology
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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