Effects of endurance training on tissue glutathione homeostasis and lipid peroxidation in streptozotocin-induced diabetic rats.

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Title Effects of endurance training on tissue glutathione homeostasis and lipid peroxidation in streptozotocin-induced diabetic rats.
Author Vider, Jelena
Journal Name Scandinavian Journal of Medicine & Science in Sports
Year Published 2002
Place of publication Copenhagen, Denmark
Publisher Blackwell Munksgaard
Abstract The aims of our study were to assess whether endurance training strengthens glutathione-dependent antioxidant defenses and decreases oxidative stress in experimental diabetes. Streptozotocin-induced diabetic rats were divided into trained and untrained groups, which were further divided into resting and acute exercise groups. Endurance training consisted of treadmill running for 8 weeks. For acute exhaustive exercise, graded treadmill running was conducted until exhaustion. Eight weeks' treadmill training increased the endurance, favorably decreased lipid peroxidation as measured by thiobarbituric acid reactive substances but not conjugated dienes levels in kidney and vastus lateralis muscle and upregulated glutathione peroxidase in red gastrocnemius muscle. However, it adversely decreased total glutathione level and glutathione peroxidase activity in kidney. Acute exhaustive exercise up-regulated glutathione peroxidase activity in liver. Endurance training did not prevent the increase in thiobarbituric acid reactive substances level in liver due to acute exhaustive exercise. Activities of glutathione disulfide reductase and glutathione S-transferase were not affected. Even though endurance training appeared to upregulate glutathione dependent antioxidant defense in skeletal muscle and to decrease lipid peroxidation in kidney and vastus lateralis muscle as measured by TBARS, our results suggests that beneficial effects of 8 weeks of endurance training are limited in this rat model of uncontrolled diabetes mellitus.
Peer Reviewed Yes
Published Yes
Alternative URI http://dx.doi.org/10.1034/j.1600-0838.2002.120307.x
Volume 12
Issue Number 3
Page from 163
Page to 170
ISSN 0905-7188
Date Accessioned 2012-04-10; 2012-07-12T23:33:15Z
Date Available 2012-07-12T23:33:15Z
Research Centre Heart Foundation Research Centre; Molecular Basis of Disease
Faculty Griffith Health Faculty
Subject Sports Medicine
URI http://hdl.handle.net/10072/45840
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1x

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