Oxidative stress before and after exercise conditioning in patients following surgical revascularization of the myocardium.

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Title Oxidative stress before and after exercise conditioning in patients following surgical revascularization of the myocardium.
Author Vider, Jelena
Journal Name International Journal of Rehabilitation Research
Year Published 2002
Place of publication London, UK
Publisher Lippincott Williams & Wilkins, Inc.
Abstract The main purpose of the study was to evaluate changes in the extent of oxidative stress and its associations with the indices of cardiorespiratory reserve and functional capacity in 35 patients enrolled in a 12-week exercise conditioning programme 2-4 weeks after surgical revascularization of the myocardium. The following markers of oxidative stress were measured spectrophotometrically before and after the programme: lipid peroxidation products (thiobarbituric acid reactive substances, diene conjugates and lipid hydroperoxide) and markers of blood antioxidant status (blood glutathione markers, blood antioxidative capacity and lag phase of low-density lipoprotein (LDL)). To evaluate the functional indices of the cardiorespiratory system the patients underwent bicycle cardiopulmonary testing before entering and after completing the programme. On the basis of peak oxygen consumption (peak VO2) +/- 1 SD, three subgroups with different aerobic capacity were identified: >/=19 ml/min per kg (GR I, n = 7), 11-19 ml/min per kg (GR II, n = 24) and </=11 ml/min per kg (GR III, n = 5). The extent of oxidative stress was markedly elevated in all subgroups. The most significant improvement occurred at the level of lipid peroxidation products and lag phase of LDL. The indices of cardiorespiratory reserve and exercise capacity demonstrated highly significant increases, while the most favourable modifications, considering both the biochemical and functional indices, were observed in patients with the lowest aerobic capacity.
Peer Reviewed Yes
Published Yes
Publisher URI http://journals.lww.com/intjrehabilres/Abstract/2002/12000/Oxidative_stress_before_and_after_exercise.8.aspx
Volume 25
Issue Number 4
Page from 305
Page to 312
ISSN 0342-5282
Date Accessioned 2012-04-10; 2012-07-12T23:34:03Z
Research Centre Heart Foundation Research Centre; Molecular Basis of Disease
Faculty Griffith Health Faculty
Subject Human Movement and Sports Science
URI http://hdl.handle.net/10072/45841
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1x

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