Physical exercise induces activation of NF-kappaB in human peripheral blood lymphocytes

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Title Physical exercise induces activation of NF-kappaB in human peripheral blood lymphocytes
Author Vider, Jelena
Journal Name Antioxidents & Redox Signalling
Year Published 2001
Place of publication United States
Publisher Mary Ann Liebert, Inc. Publishers
Abstract Current understanding of nuclear factor-kappaB (NF-kappaB) activation is derived mostly from in vitro studies, and in vivo human data are limited. This study provides first evidence showing that physical exercise (80% maximal O2 consumption, 1 h) may trigger NF-kappaB activation, as determined by electrophoretic mobility shift assay, in peripheral blood lymphocytes of physically fit young men. Supershift assay showed that the NF-kappaB protein complex contained the transcriptionally active p65 protein. Plasma levels of NF-kappaB-directed gene products such as tumor necrosis factor-alpha and interleukin-2 receptor confirmed that physical exercise caused NF-kappaB transactivation. Exercise-induced NF-kappaB activation in lymphocytes was associated with elevated levels of lipid peroxidation by-products in the plasma.
Peer Reviewed Yes
Published Yes
Alternative URI http://dx.doi.org/10.1089/152308601317203639
Volume 3
Issue Number 6
Page from 1131
Page to 1137
ISSN 1523-0864
Date Accessioned 2012-04-10; 2012-07-12T23:43:56Z
Date Available 2012-07-12T23:43:56Z
Research Centre Heart Foundation Research Centre
Faculty Griffith Health Faculty
Subject Sports Medicine
URI http://hdl.handle.net/10072/45850
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1x

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