The role of macrophage migration inhibitory factor in alphaviral induced inflammatory disease

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Title The role of macrophage migration inhibitory factor in alphaviral induced inflammatory disease
Author Herrero, Lara
Publication Title Australian Society for Medical Research
Year Published 2009
Place of publication Australia
Publisher ASMR
Abstract Introduction Ross River virus (RRV), an alphavirus of the family Togaviridae, circulates endemically in Australia, frequently causing outbreaks of polyarthritis. Macrophage migration inhibitory factor (MIF), a pro-inflammatory cytokine, has been shown to play an instrumental role in the pathogenesis of rheumatoid arthritis. Studies using a mouse model of RRV disease have found macrophages to play a key role in disease pathogenesis and clinical outcome. Given this, we hypothesise that MIF may play a role in RRV disease. Methods Using the RRV disease mouse model we subcutaneously infected mice with 104 pfu RRV. Mice were monitored for disease signs and weighed daily. The clinical signs of disease were determined by assessing grip strength and altered gait. Mice were then scarified and tissues collected to determine levels of RRV and MIF expression. Results Preliminary results indicate that there is a correlation between the regulation of MIF and RRV disease. Experiments are continuing to determine the role of additional cytokines commonly associated with MIF. Results will be confirmed using a MIF knock-out mouse and in vitro studies. Conclusion Results of this study suggest a role of MIF in RRV pathogenesis. Additionally MIF may provide a target for the development of antiviral pharmaceuticals.
Peer Reviewed No
Published Yes
Publisher URI
Conference name Australian Society for Medical Research
Location Canberra
Date From 2009-07-27
Date To 2009-07-30
Date Accessioned 2011-03-23; 2012-08-28T08:42:30Z
Research Centre Institute for Glycomics
Faculty Faculty of Science, Environment, Engineering and Technology
Subject Virology
Publication Type Conference Publications (Extract Paper)
Publication Type Code e3x

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