Olfactory discrimination predicts cognitive decline among community-dwelling older adults

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Title Olfactory discrimination predicts cognitive decline among community-dwelling older adults
Author Sohrabi, HR; Bates, KA; Weinborn, MG; Johnston, Amy Nicole Burne; Bahramian, A; Taddei, K; Laws, SM; Rodrigues, M; Moricci, M; Howard, M; Martins, G; Mackay-Sim, Alan; Gandy, SE; Martins, RN
Journal Name Translational Psychiatry
Editor Julio Licinio
Year Published 2012
Place of publication United Kingdom
Publisher Nature publishing group
Abstract The presence of olfactory dysfunction in individuals at higher risk of Alzheimer's disease has significant diagnostic and screening implications for preventive and ameliorative drug trials. Olfactory threshold, discrimination and identification can be reliably recorded in the early stages of neurodegenerative diseases. The current study has examined the ability of various olfactory functions in predicting cognitive decline in a community-dwelling sample. A group of 308 participants, aged 46–86 years old, were recruited for this study. After 3 years of follow-up, participants were divided into cognitively declined and non-declined groups based on their performance on a neuropsychological battery. Assessment of olfactory functions using the Sniffin’ Sticks battery indicated that, contrary to previous findings, olfactory discrimination, but not olfactory identification, significantly predicted subsequent cognitive decline (odds ratio=0.869; P<0.05; 95% confidence interval=0.764−0.988). The current study findings confirm previously reported associations between olfactory and cognitive functions, and indicate that impairment in olfactory discrimination can predict future cognitive decline. These findings further our current understanding of the association between cognition and olfaction, and support olfactory assessment in screening those at higher risk of dementia.
Peer Reviewed Yes
Published Yes
Alternative URI http://dx.doi.org/10.1038/tp.2012.43
Volume 2
Page from e118-1
Page to e118-7
ISSN 2158-3188
Date Accessioned 2012-06-08
Language en_US
Research Centre Centre for Health Practice Innovation; Eskitis Institute for Drug Discovery
Faculty Griffith Health Faculty
Subject Sensory Systems
URI http://hdl.handle.net/10072/47110
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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