Low-Level Plasmodium falciparum Blood-Stage Infection Causes Dendritic Cell Apoptosis and Dysfunction in Healthy Volunteers

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Title Low-Level Plasmodium falciparum Blood-Stage Infection Causes Dendritic Cell Apoptosis and Dysfunction in Healthy Volunteers
Author Woodberry, Tonia; Minigo, Gabriela; Piera, Kim A; Amante, Fiona H.; Pinzon-Charry, Alberto; Good, Michael Francis; Lopez, Alejandro; Entgwerda, Christian R.; McCarthy, James S.; Anstey, NIcholas M.
Journal Name Journal of Infectious Diseases
Year Published 2012
Place of publication United States
Publisher Oxford University Press
Abstract Background. Dendritic cells (DCs) are highly specialized antigen-presenting cells that are crucial for initiation of immune responses. During naturally acquired malaria, DC number and function is reduced. Methods. The timing of, parasitemia threshold of, and contribution of apoptosis to DC loss were prospectively evaluated in 10 men after experimental challenge with approximately 1800 Plasmodium falciparum-parasitized red blood cells (pRBCs) and after drug cure initiated at a parasite level of ≥1000 parasites/mL. Results. The nadir levels of total, myeloid, and plasmacytoid DCs occurred 8 days after infection. DC loss was partially attributable to apoptosis, which was first detected on day 5 (median parasite level, 238 parasites/mL) and maximal at day 7. Remaining DCs exhibited a reduced ability to uptake particulate antigen. DC numbers recovered approximately 60 hours after antimalarial drug administration. There was no loss of DC number or function before or after drug cure in 5 men inoculated with <180 pRBCs and treated on day 6, when their parasite level was approximately 200 parasites/mL. Conclusions. Plasmodium causes DC loss in vivo, which is at least partially explained by apoptosis in response to blood-stage parasites. In primary infection, loss of DC number and function occurs early during the prepatent period and before or with onset of clinical symptoms. These findings may explain in part the inadequate development of immunity to blood-stage malaria infection.
Peer Reviewed Yes
Published Yes
Alternative URI http://dx.doi.org/10.1093/infdis/jis366
Volume 206
Issue Number 3
Page from 333
Page to 340
ISSN 0022-1899
Date Accessioned 2012-07-12
Language en_US
Research Centre Institute for Glycomics
Faculty Faculty of Science, Environment, Engineering and Technology
Subject Host-Parasite Interactions; Immunology
URI http://hdl.handle.net/10072/47149
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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