A3 adenosine receptor-mediated protection of the ischemic heart

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Title A3 adenosine receptor-mediated protection of the ischemic heart
Author Headrick, John Patrick; Peart, Jason Nigel John
Journal Name Vascular Pharmacology
Year Published 2005
Place of publication United States
Publisher Elsevier
Abstract The A3 adenosine receptor (A3AR) is attributed with multiple beneficial actions in ischemic–reperfused myocardium, including modulation of oncotic and apoptotic cell death and enhancement of contractile function. Additionally, the A3AR may attenuate vascular dysfunction and improve long-term outcome from myocardial insult (modulating hypertrophy and angiogenesis). Available evidence indicates that this receptor sub-type is minimally activated by endogenous adenosine during ischemia (A3AR antagonists exerting no effects on ischemic outcome), and is thus amenable to activation with exogenous agonists. Protected phenotypes arise with both pre- and post-ischemic treatment with A3AR agonists, and transient A3AR agonism also triggers early and delayed preconditioned states. The molecular basis for the varied protective actions of the A3AR remains poorly defined, and may well vary between species (e.g. rodent vs. human) and protective responses (e.g. acute vs. delayed protection). Nonetheless, A3ARs may be more promising as therapeutic "anti-ischemic" targets compared with other adenosine receptor subtypes, since A3AR agonists elicit fewer and less significant side-effects. This review addresses current knowledge and controversy regarding the protective actions (and associated signaling) of A3ARs in ischemic–reperfused heart.
Peer Reviewed Yes
Published Yes
Alternative URI http://dx.doi.org/10.1016/j.vph.2005.02.009
Copyright Statement Copyright 2005 Elsevier : Reproduced in accordance with the copyright policy of the publisher : This journal is available online - use hypertext links
Volume 42
Issue Number 5-6
Page from 271
Page to 279
ISSN 1537-1891
Date Accessioned 2006-03-15
Language en_AU
Research Centre Menzies Health Institute Qld; Heart Foundation Research Centre
Faculty Griffith Health Faculty
Subject PRE2009-Systems Physiology
URI http://hdl.handle.net/10072/4736
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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