Infection-induced IL-10 and JAK-STAT: A review of the molecular circuitry controlling immune hyperactivity in response to pathogenic microbes

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Title Infection-induced IL-10 and JAK-STAT: A review of the molecular circuitry controlling immune hyperactivity in response to pathogenic microbes
Author Carey, Alison; Tan, CK; Ulett, Glen Charles
Journal Name JAK-STAT
Year Published 2012
Place of publication United States
Publisher Landes Bioscience
Abstract Generation of effective immune responses against pathogenic microbes depends on a fine balance between pro- and antiinflammatory responses. Interleukin-10 (IL-10) is essential in regulating this balance and has garnered renewed interest recently as a modulator of the response to infection at the JAK-STAT signaling axis of host responses. Here, we examine how IL-10 functions as the ‘master regulator’ of immune responses through JAK-STAT, and provide a perspective from recent insights on bacterial, protozoan, and viral infection model systems. Pattern recognition and subsequent molecular events that drive activation of IL-10-associated JAK-STAT circuitry are reviewed and the implications for microbial pathogenesis are discussed.
Peer Reviewed Yes
Published Yes
Alternative URI http://dx.doi.org/10.4161/jkst.19918
Copyright Statement Copyright remains with the author[s] 2012. This is the author-manuscript version of this paper. It is posted here with permission of the copyright owner[s] for your personal use only. No further distribution permitted. For information about this journal please refer to the journal’s website or contact the author[s].
Volume 1
Issue Number 3
Page from 1
Page to 9
ISSN 2162-3996
Date Accessioned 2012-07-09
Date Available 2013-08-29T22:59:17Z
Language en_US
Research Centre Griffith Health Institute; Molecular Basis of Disease
Faculty Griffith Health Faculty
Subject Innate Immunity; Medical Microbiology
URI http://hdl.handle.net/10072/47639
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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