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dc.contributor.authorYudi, M
dc.contributor.authorOmera, L
dc.contributor.authorMcCubbery, N
dc.contributor.authorDick, S
dc.contributor.authorJayasinghe, R
dc.contributor.authorHamilton-Craig, I
dc.date.accessioned2017-05-03T14:20:22Z
dc.date.available2017-05-03T14:20:22Z
dc.date.issued2012
dc.date.modified2014-10-09T00:55:55Z
dc.identifier.issn0037-5675
dc.identifier.urihttp://hdl.handle.net/10072/47776
dc.description.abstractIntroduction Familial hypercholesterolaemia (FH) is caused by an autosomal dominant mutation of the low density lipoprotein (LDL) receptor gene, resulting in high levels of LDL cholesterol and premature coronary artery disease (P-CAD). Studies have shown low detection rates of FH in patients admitted with P-CAD and suboptimal therapy at discharge. Methods Males aged = 55 years and females aged = 60 years who were admitted with P-CAD to the Gold Coast Hospital during a 12-month period were included in the study. The demographics, cardiovascular risk factors, examination findings, admission and discharge cardiac medications and provisional diagnoses were recorded. Diagnosis of FH was made according to internationally accepted criteria. Resu lts 210 patients were included in the study; 60% were male and 40% female (mean age 48 and 50 years, respectively). Only 96 (46%) patients' fasting lipid levels were documented (LDL-C 2.75 ᠱ.0 mmol/L), and FH was considered in three (1%) cases. According to the Dutch Lipid Network criteria, three (1%) patients had probable FH, 50 (24%) had possible FH and 60 (29%) had unlikely FH. Of the 53 patients with probable or possible FH, 12 (23%) were discharged without statin therapy and 13 (25%) on the maximum recommended statin dose. Conclusion Our study has found inadequate documentation and screening for FH and suboptimal therapy in patients admitted with P-CAD. We propose a simple screening tool that can be applied to all patients admitted with suspected P-CAD in order to improve the detection rate of FH and its management.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherSingapore Medical Association
dc.publisher.placeSingapore
dc.publisher.urihttp://www.sma.org.sg/Publications/articles.aspx?ID=BF2D7B8D-5178-4DC7-AFB7-2D83161FB991
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom174
dc.relation.ispartofpageto178
dc.relation.ispartofissue3
dc.relation.ispartofjournalSingapore Medical Journal
dc.relation.ispartofvolume53
dc.rights.retentionY
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.subject.fieldofresearchcode32
dc.titleSuboptimal consideration and management of potential familial hypercholesterolaemia in patients with suspected premature coronary artery disease
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2012
gro.hasfulltextNo Full Text
gro.griffith.authorHamilton-Craig, Ian


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