Increased Biological oxidation and reduced anti-oxidant enzyme activity in pre-eclamptic placentae

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Title Increased Biological oxidation and reduced anti-oxidant enzyme activity in pre-eclamptic placentae
Author Vanderlelie, Jessica Joan; Venardos, Kylie; Clifton, V.L.; Gude, N.M.; Clarke, Francis Michael; Perkins, Anthony Vincent
Journal Name Placenta
Year Published 2005
Place of publication UK
Publisher W.B Saunders
Abstract Oxidative stress occurs when cellular levels of reactive oxygen species exceed anti-oxidant capabilities and has been implicated in the pathogenesis of pre-eclampsia. In this study we have examined the tissue levels of endogenous anti-oxidant proteins (superoxide dismutase, glutathione peroxidase, thioredoxin reductase and thioredoxin) and the level of lipid and protein oxidation in placental samples from normal and pre-eclamptic pregnancies. Pre-eclamptic tissue homogenates demonstrated significantly increased levels of lipid peroxidation ( protein versus protein, P<0.001) and a trended increase in protein carbonyl concentration ( protein versus protein) when compared to controls. The levels and activities of the anti-oxidant proteins superoxide dismutase ( protein versus protein, P<0.02), thioredoxin reductase ( protein versus protein, P=0.02), thioredoxin ( protein versus protein, P=0.02) and glutathione peroxidase ( protein versus , P<0.02) were all found to be significantly reduced when comparing pre-eclamptic placental tissue homogenates to gestational age-matched control placentae from non-pre-eclamptic pregnancies. The results of this study demonstrate a decreased enzymatic anti-oxidant capacity and increased oxidation in placental tissue from pre-eclamptic women, which may contribute to the pathogenesis of this complex disorder.
Peer Reviewed Yes
Published Yes
Publisher URI
Alternative URI
Volume 26
Page from 53
Page to 58
ISSN 0143-4004
Date Accessioned 2006-02-03
Language en_AU
Research Centre Menzies Health Institute Qld
Faculty Griffith Health Faculty
Subject PRE2009-Biochemistry and Cell Biology
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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