Increased Biological oxidation and reduced anti-oxidant enzyme activity in pre-eclamptic placentae

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Title Increased Biological oxidation and reduced anti-oxidant enzyme activity in pre-eclamptic placentae
Author Vanderlelie, Jessica Joan; Venardos, Kylie; Clifton, V.L.; Gude, N.M.; Clarke, Francis Michael; Perkins, Anthony Vincent
Journal Name Placenta
Year Published 2005
Place of publication UK
Publisher W.B Saunders
Abstract Oxidative stress occurs when cellular levels of reactive oxygen species exceed anti-oxidant capabilities and has been implicated in the pathogenesis of pre-eclampsia. In this study we have examined the tissue levels of endogenous anti-oxidant proteins (superoxide dismutase, glutathione peroxidase, thioredoxin reductase and thioredoxin) and the level of lipid and protein oxidation in placental samples from normal and pre-eclamptic pregnancies. Pre-eclamptic tissue homogenates demonstrated significantly increased levels of lipid peroxidation ( protein versus protein, P<0.001) and a trended increase in protein carbonyl concentration ( protein versus protein) when compared to controls. The levels and activities of the anti-oxidant proteins superoxide dismutase ( protein versus protein, P<0.02), thioredoxin reductase ( protein versus protein, P=0.02), thioredoxin ( protein versus protein, P=0.02) and glutathione peroxidase ( protein versus , P<0.02) were all found to be significantly reduced when comparing pre-eclamptic placental tissue homogenates to gestational age-matched control placentae from non-pre-eclamptic pregnancies. The results of this study demonstrate a decreased enzymatic anti-oxidant capacity and increased oxidation in placental tissue from pre-eclamptic women, which may contribute to the pathogenesis of this complex disorder.
Peer Reviewed Yes
Published Yes
Publisher URI http://www.elsevier.com/wps/find/journaldescription.cws_home/623064/description#description
Alternative URI http://dx.doi.org/10.1016/j.placenta.2004.04.002
Volume 26
Page from 53
Page to 58
ISSN 0143-4004
Date Accessioned 2006-02-03
Language en_AU
Research Centre Griffith Health Institute
Faculty Griffith Health Faculty
Subject PRE2009-Biochemistry and Cell Biology
URI http://hdl.handle.net/10072/4778
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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