3,4'-Linked bis(piperidines) related to the haliclonacyclamine class of marine alkaloids: synthesis using crossed-aldol chemistry and preliminary biological evaluations

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Title 3,4'-Linked bis(piperidines) related to the haliclonacyclamine class of marine alkaloids: synthesis using crossed-aldol chemistry and preliminary biological evaluations
Author Banwell, Martin G.; Coster, Mark J; Hungerford, Natasha Lynn; Garson, Mary J.; Su, Stephen; Kotze, Andrew C.; Munro, Murray H. G.
Journal Name Organic & Biomolecular Chemistry
Year Published 2012
Place of publication United Kingdom
Publisher Royal Society of Chemistry
Abstract Compounds 2–5, incorporating various elements of the 3,4′-bis(piperidine) core associated with the sponge-derived alkaloid haliclonacyclamine A (HA, 1), have been prepared through, inter alia, aldol-type reactions of N-substituted piperidin-4-ones and certain derivatives. Screening of these compounds in various assays, including an ecological one, reveals that compound 5 exhibits allelochemical properties similar to those associated with HA itself.
Peer Reviewed Yes
Published Yes
Alternative URI http://dx.doi.org/10.1039/C1OB06418E
Volume 10
Issue Number 1
Page from 154
Page to 161
ISSN 1477-0520
Date Accessioned 2012-07-12
Language en_US
Research Centre Eskitis Institute for Drug Discovery
Faculty Faculty of Science, Environment, Engineering and Technology
Subject Organic Chemical Synthesis
URI http://hdl.handle.net/10072/48209
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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