3,4'-Linked bis(piperidines) related to the haliclonacyclamine class of marine alkaloids: synthesis using crossed-aldol chemistry and preliminary biological evaluations
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| Title | 3,4'-Linked bis(piperidines) related to the haliclonacyclamine class of marine alkaloids: synthesis using crossed-aldol chemistry and preliminary biological evaluations |
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| Author | Banwell, Martin G.; Coster, Mark J; Hungerford, Natasha Lynn; Garson, Mary J.; Su, Stephen; Kotze, Andrew C.; Munro, Murray H. G. |
| Journal Name | Organic & Biomolecular Chemistry |
| Year Published | 2012 |
| Place of publication | United Kingdom |
| Publisher | Royal Society of Chemistry |
| Abstract | Compounds 2–5, incorporating various elements of the 3,4′-bis(piperidine) core associated with the sponge-derived alkaloid haliclonacyclamine A (HA, 1), have been prepared through, inter alia, aldol-type reactions of N-substituted piperidin-4-ones and certain derivatives. Screening of these compounds in various assays, including an ecological one, reveals that compound 5 exhibits allelochemical properties similar to those associated with HA itself. |
| Peer Reviewed | Yes |
| Published | Yes |
| Alternative URI | http://dx.doi.org/10.1039/C1OB06418E |
| Volume | 10 |
| Issue Number | 1 |
| Page from | 154 |
| Page to | 161 |
| ISSN | 1477-0520 |
| Date Accessioned | 2012-07-12 |
| Date Available | 2013-06-07T04:38:39Z |
| Language | en_US |
| Research Centre | Eskitis Institute for Drug Discovery |
| Faculty | Faculty of Science, Environment, Engineering and Technology |
| Subject | Organic Chemical Synthesis |
| URI | http://hdl.handle.net/10072/48209 |
| Publication Type | Journal Articles (Refereed Article) |
| Publication Type Code | c1 |
Please use this identifier to cite this record: http://hdl.handle.net/10072/48209
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