Multipotent Stem Cells From Adult Olfactory Mucosa

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Title Multipotent Stem Cells From Adult Olfactory Mucosa
Author Murrell, Wayne George; Feron, Francois; Wetzig, Andrew Roberts; Cameron, Nicholas; Splatt, Karisha Jade; Bellette, Bernadette; Bianco, John; Perry, Chris; Lee, Gabriel; Mackay-Sim, Alan
Journal Name Developmental Dynamics
Editor Gary Schoenwolf
Year Published 2005
Place of publication Hoboken, New Jersey
Publisher Wiley-Liss
Abstract Multipotent stem cells are thought to be responsible for the generation of new neurons in the adult brain. Neurogenesis also occurs in an accessible part of the nervous system, the olfactory mucosa. We show here that cells from human olfactory mucosa generate neurospheres that are multipotent in vitro and when transplanted into the chicken embryo. Cloned neurosphere cells show this multipotency. Multipotency was evident without prior culture in vitro: cells dissociated from adult rat olfactory mucosa generate leukocytes when transplanted into bone-marrow irradiated hosts and cells dissociated from adult mouse olfactory epithelium generated numerous cell types when transplanted into the chicken embryo. It is unlikely that these results can be attributed to hematopoietic precursor contamination or cell fusion. These results demonstrate the existence of a multipotent stem-like cell in the olfactory mucosa useful for autologous transplantation therapies and for cellular studies of disease.
Peer Reviewed Yes
Published Yes
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Copyright Statement Copyright 2005 John Wiley & Sons, Ltd. Self-archiving of the author-manuscript version is not yet supported by this publisher. Please refer to the journal link for access to the definitive, published version or contact the author for more information.
Volume 233
Issue Number 2
Page from 496
Page to 515
ISSN 1058-8388
Date Accessioned 2006-02-24
Language en_AU
Research Centre Eskitis Institute for Drug Discovery
Faculty Faculty of Science
Subject PRE2009-Cell Development (incl. Cell Division and Apoptosis)
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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