Derivatives of pentamidine designed to target the Leishmania lipophosphoglycan

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Title Derivatives of pentamidine designed to target the Leishmania lipophosphoglycan
Author Kramp, Kari L.; DeWitt, Kristin; Flora, Jason W.; Muddiman, David C.; Slunt, Kelli M.; Houston, Todd Ashley
Journal Name Tetrahedron Letters
Year Published 2005
Place of publication Oxford, UK
Publisher Elsevier Ltd / Pergmon
Abstract The Leishmania lipophosphoglycan (LPG) is the most abundant cell surface glycoconjugate of a family of infectious protozoa. Pentamidine, a common drug used in the treatment of Leishmania infections, has been modified with boronic acids so that it might bind more selectively to the phosphodisaccharide repeating unit of the LPG. This could serve to target the drug to the protozoan surface and increase its efficacy in vivo
Peer Reviewed Yes
Published Yes
Publisher URI http://www.elsevier.com/wps/find/journaldescription.cws_home/233/description#description
Copyright Statement Copyright 2005 Elsevier : Reproduced in accordance with the copyright policy of the publisher : This journal is available online - use hypertext links.
Volume 46
Page from 695
Page to 698
ISSN 0040-4039
Date Accessioned 2006-01-30
Date Available 2007-03-19T21:34:25Z
Language en_AU
Research Centre Institute for Glycomics
Faculty Faculty of Science
Subject Biological and Medical Chemistry
URI http://hdl.handle.net/10072/4947
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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