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dc.contributor.authorWellard, RM
dc.contributor.authorBriellmann, RS
dc.contributor.authorWilson, JC
dc.contributor.authorKalnins, RM
dc.contributor.authorAnderson, DP
dc.contributor.authorFederico, P
dc.contributor.authorFabinyi, GCA
dc.contributor.authorScheffer, IE
dc.contributor.authorHarvey, AS
dc.contributor.authorJackson, GD
dc.date.accessioned2017-05-03T12:19:07Z
dc.date.available2017-05-03T12:19:07Z
dc.date.issued2004
dc.date.modified2012-02-10T01:11:18Z
dc.identifier.issn0006-8950
dc.identifier.doi10.1093/brain/awh157
dc.identifier.urihttp://hdl.handle.net/10072/5063
dc.description.abstractThis study analyses the evolution of metabolite changes in an 8-year-old boy with focal Rasmussen encephalitis. Five MRI examinations, including magnetic resonance spectroscopy (MRS) were performed over 9 months. Following complex partial status, T2-weighted imaging showed transient dramatic signal increase in the left superior temporal gyrus and mesial temporal structures. Subsequent scans showed resolution of the swelling and signal normalization, with development of slight focal atrophy. MRS after status showed a reduction in N-acetylaspartate, total creatine and trimethylamines. Subsequent scans showed complete resolution of these metabolite abnormalities, followed later by development of further abnormal metabolite values. Lactate and glutamine/glutamate were elevated after status. After surgery, ex vivo high-field 1H and 31P MRS confirmed metabolite abnormalities (elevated choline and decreased aspartate, N-acetylaspartate, [1H]glutamate together with altered [31P]phospholipid ratios. These findings suggested active disease process in the anterior region of the excised superior temporal gyrus. We conclude that Rasmussen encephalitis is a combination of progressive encephalitic damage and fluctuating seizure effects, in which neuronal injury and recovery can occur. MRS measurements at a single time point should consider the fluctuating metabolite profile related to seizure activity.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent292080 bytes
dc.format.extent47882 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.languageEnglish
dc.language.isoeng
dc.publisherOxford University Press
dc.publisher.placeOxford
dc.publisher.urihttp://brain.oxfordjournals.org/
dc.relation.ispartofpagefrom1302
dc.relation.ispartofpageto1312
dc.relation.ispartofissue6
dc.relation.ispartofjournalBrain
dc.relation.ispartofvolume127
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.subject.fieldofresearchPsychology
dc.subject.fieldofresearchHealth sciences
dc.subject.fieldofresearchcode32
dc.subject.fieldofresearchcode52
dc.subject.fieldofresearchcode42
dc.titleLongitudinal study of MRS metabolites in Rasmussens encephalitis
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.rights.copyrightThis is a pre-copy-editing, author-produced PDF of an article accepted for publication in Brain following peer review. The definitive publisher-authenticated version Brain (2004), 127, 1302-1312 is available online at: http://dx.doi.org/10.1093/brain/awh157
gro.date.issued2004
gro.hasfulltextFull Text
gro.griffith.authorWilson, Jenny C.


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