dc.contributor.author | Stapelberg, M | |
dc.contributor.author | Tomasetti, M | |
dc.contributor.author | Alleva, R | |
dc.contributor.author | Gellert, N | |
dc.contributor.author | Procopio, A | |
dc.contributor.author | Neuzil, J | |
dc.contributor.editor | W. Baumeister | |
dc.date.accessioned | 2017-05-03T12:22:18Z | |
dc.date.available | 2017-05-03T12:22:18Z | |
dc.date.issued | 2004 | |
dc.date.modified | 2010-08-17T05:03:39Z | |
dc.identifier.issn | 0006-291X | |
dc.identifier.doi | 10.1016/j.bbrc.2004.04.072 | |
dc.identifier.uri | http://hdl.handle.net/10072/5502 | |
dc.description.abstract | a-Tocopheryl succinate (a-TOS), a redox-silent analogue of vitamin E, inhibits malignant mesotheliomas (MM) in a pre-clinical model. Here we investigated the underlying mechanism. Exposure of MM cells to a-TOS triggered apoptosis at higher and inhibited proliferation at lower concentrations, while this effect was not observed in non-malignant mesothelial cells. Sub-apoptotic doses of a-TOS caused down-regulation of fibroblast growth factor receptor-1 (FGFR1) selectively in MM cells, while the effect on FGFR2 was only marginal. FGF1 and FGF2 enhanced MM cell proliferation that was suppressed by a-TOS. Over-expression of E2F1, a transcriptional factor of FGFR1, but not its dominant-negative counterpart, partially blocked the inhibitory activity of a-TOS on MM cell proliferation. Our data suggest a novel mechanism by which a clinically intriguing agent selectively suppresses proliferation of cancer cells, as shown here for the untreatable mesotheliomas. | |
dc.description.peerreviewed | Yes | |
dc.description.publicationstatus | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Academic Press | |
dc.publisher.place | United States | |
dc.publisher.uri | http://www.elsevier.com/wps/find/journaldescription.cws_home/622790/description | |
dc.relation.ispartofpagefrom | 636 | |
dc.relation.ispartofpageto | 641 | |
dc.relation.ispartofissue | 3 | |
dc.relation.ispartofjournal | Biochemical and biophysical research communications | |
dc.relation.ispartofvolume | 318 | |
dc.subject.fieldofresearch | Medicinal and biomolecular chemistry | |
dc.subject.fieldofresearch | Biochemistry and cell biology | |
dc.subject.fieldofresearch | Medical biochemistry and metabolomics | |
dc.subject.fieldofresearchcode | 3404 | |
dc.subject.fieldofresearchcode | 3101 | |
dc.subject.fieldofresearchcode | 3205 | |
dc.title | α-Tocopheryl succinate inhibits proliferation of mesothelioma cells by selective down-regulation of fibroblast growth factor receptors | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.faculty | Griffith Health, School of Medical Science | |
gro.rights.copyright | © 2004 Elsevier : Reproduced in accordance with the copyright policy of the publisher : This journal is available online - use hypertext links. | |
gro.date.issued | 2004 | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Neuzil, Jiri | |