Xanthones from a microfungus of the genus Xylaria

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Title Xanthones from a microfungus of the genus Xylaria
Author Healy, Peter Conrad; Hocking, Ailsa; Tran-Dinh, Nai; Pitt, John I.; Shivas, Roger G.; Mitchell, Jennifer; Kotiw, Mike; Davis, Rohan Andrew
Journal Name Phytochemistry
Year Published 2004
Place of publication UK
Publisher Elsevier / Pergamon
Abstract Chemical investigations of a microfungus Xylaria sp. isolated from the Australian rainforest tree Glochidion ferdinandi have afforded two new natural products, 2-hydroxy-6-methyl-8-methoxy-9-oxo-9H-xanthene-1-carboxylic acid (1) and 2-hydroxy-6-hydroxymethyl-8-methoxy-9-oxo-9H-xanthene-1-carboxylic acid (2). Compound 1 has previously been synthesised but only partially characterised. Methylation of 1 using diazomethane afforded the crystalline compound 2,8-dimethoxy-6-methyl-9-oxo-9H-xanthene-1-carboxylic acid methyl ester (3), whose structure was determined by single crystal X-ray analysis. This paper reports the full spectroscopic characterisation of compounds 1–3 by NMR, UV, IR and MS data. All compounds were inactive in a brine shrimp lethality assay and several antimicrobial screens.
Peer Reviewed Yes
Published Yes
Publisher URI http://www.sciencedirect.com/science/journal/00319422
Alternative URI http://dx.doi.org/10.1016/j.phytochem.2004.07.019
Copyright Statement Copyright 2004 Elsevier : Reproduced in accordance with the copyright policy of the publisher : This journal is available online - use hypertext links. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher.
Volume 65
Issue Number 16
Page from 2373
Page to 2378
ISSN 0031-9422
Date Accessioned 2005-03-14
Language en_AU
Research Centre Eskitis Institute for Drug Discovery
Faculty Faculty of Science
Subject PRE2009-Organic Chemistry
URI http://hdl.handle.net/10072/5718
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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