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dc.contributor.authorSchroder, W
dc.contributor.authorCloonan, N
dc.contributor.authorBushell, G
dc.contributor.authorSculley, T
dc.date.accessioned2017-05-03T11:32:22Z
dc.date.available2017-05-03T11:32:22Z
dc.date.issued2004
dc.date.modified2009-12-05T05:16:51Z
dc.identifier.issn0378-1119
dc.identifier.doi10.1016/j.gene.2004.07.001
dc.identifier.urihttp://hdl.handle.net/10072/5759
dc.description.abstractLimited but significant sequence similarity has been observed between an uncharacterized human protein, SIN1, and the S. pombe SIN1, Dictyostelium RIP3 and S. cerevisiae AVO1 proteins. The human Sin1 gene has been automatically predicted (MAPKAP1; GenBank accession number NM_024117); however, this sequence appears to be incomplete. In this study, we have cloned and characterized the full-length human Sin1 mRNA and identified a highly conserved domain that defines the family of SIN1 orthologues, members of which are widely distributed in the fungal and metazoan kingdoms. We demonstrate that Sin1 transcripts can use alternative polyadenylation signals and describe a number of Sin1 splice variants that potentially encode functionally different isoforms.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeAmsterdam, Holland
dc.publisher.urihttp://www.elsevier.com/wps/find/journaldescription.cws_home/506033/description#description
dc.relation.ispartofpagefrom17
dc.relation.ispartofpageto23
dc.relation.ispartofjournalGene
dc.relation.ispartofvolume339
dc.subject.fieldofresearchGenetics
dc.subject.fieldofresearchZoology
dc.subject.fieldofresearchMedical microbiology
dc.subject.fieldofresearchBiochemistry and cell biology
dc.subject.fieldofresearchBioinformatics and computational biology
dc.subject.fieldofresearchcode3105
dc.subject.fieldofresearchcode3109
dc.subject.fieldofresearchcode3207
dc.subject.fieldofresearchcode3101
dc.subject.fieldofresearchcode3102
dc.titleAlternative polyadenylation and splicing of mRNAs transcribed from the human Sin1 gene
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.rights.copyright© 2004 Elsevier : Reproduced in accordance with the copyright policy of the publisher : This journal is available online - use hypertext links.
gro.date.issued2004
gro.hasfulltextNo Full Text
gro.griffith.authorBushell, Gillian R.
gro.griffith.authorSchroder, Wayne


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