Alternative polyadenylation and splicing of mRNAs transcribed from the human Sin1 gene

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Title Alternative polyadenylation and splicing of mRNAs transcribed from the human Sin1 gene
Author Schroder, Wayne Ashley; Cloonan, Nicole; Bushell, Gillian Robin; Sculley, Tom
Journal Name Gene
Year Published 2004
Place of publication Amsterdam, Holland
Publisher Elsevier
Abstract Limited but significant sequence similarity has been observed between an uncharacterized human protein, SIN1, and the S. pombe SIN1, Dictyostelium RIP3 and S. cerevisiae AVO1 proteins. The human Sin1 gene has been automatically predicted (MAPKAP1; GenBank accession number NM_024117); however, this sequence appears to be incomplete. In this study, we have cloned and characterized the full-length human Sin1 mRNA and identified a highly conserved domain that defines the family of SIN1 orthologues, members of which are widely distributed in the fungal and metazoan kingdoms. We demonstrate that Sin1 transcripts can use alternative polyadenylation signals and describe a number of Sin1 splice variants that potentially encode functionally different isoforms.
Peer Reviewed Yes
Published Yes
Publisher URI http://www.elsevier.com/wps/find/journaldescription.cws_home/506033/description#description
Alternative URI http://dx.doi.org/10.1016/j.gene.2004.07.001
Copyright Statement Copyright 2004 Elsevier : Reproduced in accordance with the copyright policy of the publisher : This journal is available online - use hypertext links.
Volume 339
Page from 17
Page to 23
ISSN 0378-1119
Date Accessioned 2005-03-10
Date Available 2009-12-05T05:16:51Z
Language en_AU
Research Centre Griffith Medical Research College
Faculty Faculty of Science
Subject PRE2009-Gene Expression
URI http://hdl.handle.net/10072/5759
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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