Recent strategies in the search for new anti-influenza therapies

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Title Recent strategies in the search for new anti-influenza therapies
Author Wilson, Jenny; von Itzstein, Mark
Journal Name Current Drug Targets
Editor Francis J Castellino
Year Published 2003
Place of publication The Netherlands
Publisher Bentham Science Publishers Ltd
Abstract Influenza is a highly contagious, acute upper respiratory tract disease caused by influenza virus, a member of the Orthomyxoviridae family. The viral particles have two surface antigens, haemagglutinin and sialidase (neuraminidase) that extensively decorate the surface of the virus and have been implicated in viral attachment and fusion, and the release of virion progeny, respectively. The receptor for haemagglutinin is the terminal sialic acid residue of host cell surface sialyloligosaccharides, while sialidase catalyses the hydrolysis of terminal sialic acid residues from sialyloligosaccharides. Extensive crystallographic studies of both these proteins have revealed that the residues that interact with the sialic acid are strictly conserved. Therefore, these proteins make attractive targets for the design of drugs to halt the progression of the virus. Recent successful efforts in the search for new cures for influenza have led to the development of three clinically-useful anti-influenza drugs. All three are potent, selective inhibitors of influenza virus A and B sialidase. Strategies for the development of haemagglutinin inhibitors have also been devised.
Peer Reviewed Yes
Published Yes
Publisher URI http://www.bentham.org/cdt/
Alternative URI http://www.bentham.org/cdt/contabs/cdt4-5.htm##link4
Copyright Statement Copyright 2003 Bentham Science Publishers. Please refer to the journal's website for access to the definitive, published version.
Volume 4
Issue Number 5
Page from 389
Page to 408
ISSN 1389-4501
Date Accessioned 2004-03-19
Date Available 2012-02-10T02:56:21Z
Language en_US
Research Centre Institute for Glycomics
Faculty Institute for Glycomics
Subject PRE2009-Organic Chemical Synthesis
URI http://hdl.handle.net/10072/5842
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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