dc.contributor.author | Rose'Meyer, RB | |
dc.contributor.author | Harrison, GJ | |
dc.contributor.author | Headrick, JP | |
dc.contributor.editor | M C Michel | |
dc.date.accessioned | 2017-05-03T11:37:01Z | |
dc.date.available | 2017-05-03T11:37:01Z | |
dc.date.issued | 2003 | |
dc.date.modified | 2010-07-30T07:19:03Z | |
dc.identifier.issn | 0028-1298 | |
dc.identifier.doi | 10.1007/s00210-002-0678-z | |
dc.identifier.uri | http://hdl.handle.net/10072/6191 | |
dc.description.abstract | In this study, we investigated the effect of noradrenaline depletion on contractile recovery in rat isolated heart following myocardial ischaemia. Groups tested included control tissues and hearts from reserpinised rats. Reserpine 1 mg/kg s.c. was injected into rats 18 to 24 h prior to experiments. Hearts underwent 15 min global normothermic ischaemia followed by 30 min reperfusion. Functional data (end diastolic pressure (EDP), heart rate (HR), left ventricular developed pressure (LVDP), dP/dtmax, dP/dtmin) showed that contractile function following ischaemia-reperfusion is unaffected by reserpinisation. However, pre- and post-ischaemic coronary flow rates (CFR) were increased by 16 to 38% in hearts from reserpinised rats versus control hearts. Pre-ischaemic CFRs in control hearts (11.17-0.67 ml/inm1.g tissuem1, n=9) were significantly lower then CFRs derived from reserpinised rat hearts (14.57-0.72 ml/minm1/g tissuem1, n=10). Post-ischaemic reactive hyperaemia was evident in all groups. CFRs in reserpinised hearts remained elevated when compared to pre-ischaemic values through reperfusion (P<0.05). Reserpine treatment did not significantly alter pre- or post-ischaemic adenosine efflux. The A2B adenosine receptor antagonist alloxazine (10 wM) attenuated pre- and post-ischaemic CFRs in both control and reserpinised hearts (P<0.05) without altering the hyperaemic response while the A2A adenosine receptor antagonist 8-(3-chlorostyryl) caffeine (1 wM) did not alter CFRs in both groups. The A3 adenosine receptor antagonist MRS1191 (0.1 wM) increased CFR in control and reserpinised hearts (P<0.05). Catecholamine depletion with reserpinisation enhances the responsiveness of the coronary resistance vessels to endogenous adenosine through activation of the A2B adenosine receptor. | |
dc.description.peerreviewed | Yes | |
dc.description.publicationstatus | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Springer-Verlag | |
dc.publisher.place | Germany | |
dc.relation.ispartofpagefrom | 266 | |
dc.relation.ispartofpageto | 273 | |
dc.relation.ispartofjournal | Naunyn-Schmiedeberg's Archives of Pharmacology | |
dc.relation.ispartofvolume | 367 | |
dc.subject.fieldofresearch | Pharmacology and pharmaceutical sciences | |
dc.subject.fieldofresearch | Medical physiology | |
dc.subject.fieldofresearchcode | 3214 | |
dc.subject.fieldofresearchcode | 3208 | |
dc.title | Enhanced adenosine A2B mediated coronary response in reserpinised rat heart. | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.faculty | Griffith Health, School of Medical Science | |
gro.date.issued | 2003 | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Headrick, John P. | |
gro.griffith.author | Harrison, Glenn J. | |
gro.griffith.author | Rose'Meyer, Roselyn B. | |