Models in which many cross-bridges attach simultaneously can explain the filament movement per ATP split during muscle contraction

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Title Models in which many cross-bridges attach simultaneously can explain the filament movement per ATP split during muscle contraction
Author Barclay, Christopher John
Journal Name International Journal of Biological Macromolecules
Year Published 2003
Place of publication Netherlands
Publisher Elsevier Science BV
Abstract Contractile filaments in skeletal muscle are moved by less than 2 nm for each ATP used. If just one cross-bridge is attached to each thin filament at any instant then this distance represents the fundamental myosin cross-bridge step size (i.e. the distance one cross-bridge moves a thin filament in one ATP-splitting cycle). However, most contraction models assume many cross-bridges are attached at any instant along each thin filament. The purpose of this study was to establish whether the net filament sliding per ATP used could be explained quantitatively in terms of a cross-bridge model in which multiple cross-bridges are attached along each thin filament. It was found that the relationship between net filament sliding per ATP split and the load against which the muscle shortens is compatible with such a model and furthermore predicts that the cross-bridge step size is between 7.5 and 12.5 nm over most of the range of loads. These values were similar for different muscle fibre types.
Peer Reviewed Yes
Published Yes
Publisher URI http://www.elsevier.com/wps/find/journaldescription.cws_home/525446/description#description
Alternative URI http://dx.doi.org/10.1016/S0141-8130(03)00047-3
Copyright Statement Copyright 2003 Elsevier : Reproduced in accordance with the copyright policy of the publisher : This journal is available online - use hypertext links.
Volume 32
Issue Number 3-5
Page from 139
Page to 147
ISSN 0141-8130
Date Accessioned 2004-03-19
Language en_AU
Research Centre Griffith Health Institute
Faculty Faculty of Nursing & Health
Subject PRE2009-Animal Physiology-Cell
URI http://hdl.handle.net/10072/6244
Publication Type Journal Articles (Refereed Article)
Publication Type Code c1

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