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dc.contributor.authorBarclay, Chris
dc.date.accessioned2017-05-03T11:39:59Z
dc.date.available2017-05-03T11:39:59Z
dc.date.issued2003
dc.date.modified2009-02-25T08:02:48Z
dc.identifier.issn01418130
dc.identifier.doi10.1016/S0141-8130(03)00047-3
dc.identifier.urihttp://hdl.handle.net/10072/6244
dc.description.abstractContractile filaments in skeletal muscle are moved by less than 2 nm for each ATP used. If just one cross-bridge is attached to each thin filament at any instant then this distance represents the fundamental myosin cross-bridge step size (i.e. the distance one cross-bridge moves a thin filament in one ATP-splitting cycle). However, most contraction models assume many cross-bridges are attached at any instant along each thin filament. The purpose of this study was to establish whether the net filament sliding per ATP used could be explained quantitatively in terms of a cross-bridge model in which multiple cross-bridges are attached along each thin filament. It was found that the relationship between net filament sliding per ATP split and the load against which the muscle shortens is compatible with such a model and furthermore predicts that the cross-bridge step size is between 7.5 and 12.5 nm over most of the range of loads. These values were similar for different muscle fibre types.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier Science
dc.publisher.placeNetherlands
dc.publisher.urihttp://www.elsevier.com/wps/find/journaldescription.cws_home/525446/description#description
dc.relation.ispartofpagefrom139
dc.relation.ispartofpageto147
dc.relation.ispartofissue3-5
dc.relation.ispartofjournalInternational Journal of Biological Macromolecules
dc.relation.ispartofvolume32
dc.subject.fieldofresearchBiochemistry and Cell Biology
dc.subject.fieldofresearchcode0601
dc.titleModels in which many cross-bridges attach simultaneously can explain the filament movement per ATP split during muscle contraction
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Health, School of Rehabilitation Sciences
gro.rights.copyright© 2003 Elsevier : Reproduced in accordance with the copyright policy of the publisher : This journal is available online - use hypertext links.
gro.date.issued2003
gro.hasfulltextNo Full Text
gro.griffith.authorBarclay, Chris


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