First clinical uterus transplantation trial: A six-month report
Author(s)
Brannstrom, Mats
Johannesson, Liza
Dahm-Kahler, Pernilla
Enskog, Anders
Molne, Johan
Kvarnstrom, Niclas
Diaz-Garcia, Cesar
Hanafy, Ashraf
Lundmark, Cecilia
Marcickiewicz, Janusz
Gabel, Markus
Groth, Klaus
Akouri, Randa
Eklind, Saskia
Holgersson, Jan
Tzakis, Andreas
Olausson, Michael
Griffith University Author(s)
Year published
2014
Metadata
Show full item recordAbstract
Objective To report the 6-month results of the first clinical uterus transplantation (UTx) trial. This type of transplantation may become a treatment of absolute uterine-factor infertility (AUFI). Design Prospective observational study. Setting University hospital. Patient(s) Nine AUFI women and their live uterine donors, the majority being mothers. Intervention(s) Live-donor UTx and low-dose induction immunosuppression. Main Outcome Measure(s) Data from preoperative investigations, surgery and follow-up for 6 months. Result(s) Durations of donor and recipient surgery ranged from 10 to 13 hours and from 4 to 6 hours, ...
View more >Objective To report the 6-month results of the first clinical uterus transplantation (UTx) trial. This type of transplantation may become a treatment of absolute uterine-factor infertility (AUFI). Design Prospective observational study. Setting University hospital. Patient(s) Nine AUFI women and their live uterine donors, the majority being mothers. Intervention(s) Live-donor UTx and low-dose induction immunosuppression. Main Outcome Measure(s) Data from preoperative investigations, surgery and follow-up for 6 months. Result(s) Durations of donor and recipient surgery ranged from 10 to 13 hours and from 4 to 6 hours, respectively. No immediate perioperative complications occurred in any of the recipients. After 6 months, seven uteri remained viable with regular menses. Mild rejection episodes occurred in four of these patients. These rejection episodes were effectively reversed by corticosteroid boluses. The two graft losses were because of acute bilateral thrombotic uterine artery occlusions and persistent intrauterine infection. Conclusion(s) The results demonstrate the feasibility of live-donor UTx with a low-dose immunosuppressive protocol.
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View more >Objective To report the 6-month results of the first clinical uterus transplantation (UTx) trial. This type of transplantation may become a treatment of absolute uterine-factor infertility (AUFI). Design Prospective observational study. Setting University hospital. Patient(s) Nine AUFI women and their live uterine donors, the majority being mothers. Intervention(s) Live-donor UTx and low-dose induction immunosuppression. Main Outcome Measure(s) Data from preoperative investigations, surgery and follow-up for 6 months. Result(s) Durations of donor and recipient surgery ranged from 10 to 13 hours and from 4 to 6 hours, respectively. No immediate perioperative complications occurred in any of the recipients. After 6 months, seven uteri remained viable with regular menses. Mild rejection episodes occurred in four of these patients. These rejection episodes were effectively reversed by corticosteroid boluses. The two graft losses were because of acute bilateral thrombotic uterine artery occlusions and persistent intrauterine infection. Conclusion(s) The results demonstrate the feasibility of live-donor UTx with a low-dose immunosuppressive protocol.
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Journal Title
Fertility and Sterility
Volume
101
Issue
5
Subject
Paediatrics and Reproductive Medicine not elsewhere classified
Clinical Sciences not elsewhere classified
Clinical Sciences
Paediatrics and Reproductive Medicine
Public Health and Health Services