Antimicrobial sesquiterpenes from the Chinese medicinal plant, Chloranthus angustifolius
Author(s)
Yang, Xinzhou
Wang, Chao
Yang, Jing
Wan, Dingrong
Lin, Qinxiong
Yang, Guangzhong
Mei, Zhinan
Feng, Yunjiang
Griffith University Author(s)
Year published
2014
Metadata
Show full item recordAbstract
Two new eudesmane-type sesquiterpenes, 9a-hydroxycurcolonol (1) and 3a-hydroxy-4-deoxy-5-dehydrocurcolonol (2), along with nine known sesquiterpenes (3-11), were isolated from the roots of Chloranthus angustifolius. The antimicrobial activities of compounds 1-11 were evaluated against five bacteria and six fungal strains. Compounds 6-11 showed potent activities against Candida albicans with MIC values ranging from 4 to 8 姯mL. The structures of the two new compounds 1 and 2 were established by a detailed analysis of their NMR and mass spectroscopic data.Two new eudesmane-type sesquiterpenes, 9a-hydroxycurcolonol (1) and 3a-hydroxy-4-deoxy-5-dehydrocurcolonol (2), along with nine known sesquiterpenes (3-11), were isolated from the roots of Chloranthus angustifolius. The antimicrobial activities of compounds 1-11 were evaluated against five bacteria and six fungal strains. Compounds 6-11 showed potent activities against Candida albicans with MIC values ranging from 4 to 8 姯mL. The structures of the two new compounds 1 and 2 were established by a detailed analysis of their NMR and mass spectroscopic data.
View less >
View less >
Journal Title
Tetrahedron Letters
Volume
55
Issue
41
Subject
Medicinal and biomolecular chemistry
Biologically active molecules
Organic chemistry