Polymeric siRNA delivery vectors: knocking down cancers with polymeric-based gene delivery systems
Author(s)
Ardana, A
Whittaker, AK
Mcmillan, NAJ
Thurecht, KJ
Griffith University Author(s)
Year published
2015
Metadata
Show full item recordAbstract
One of the most promising routes for cancer therapy that has evolved over the previous decade is the use of small-interfering RNA (siRNA) as a means of switching off genes that are responsible for tumour development. However, while siRNA and gene/antisense therapies provide alternatives to conventional chemotherapies, significant hurdles related to the delivery and efficacy of treatment must still be overcome before this technology can be used as an effective treatment for cancer and other diseases. This review highlights the issues associated with siRNA therapy in vivo, and describes the various approaches that are being ...
View more >One of the most promising routes for cancer therapy that has evolved over the previous decade is the use of small-interfering RNA (siRNA) as a means of switching off genes that are responsible for tumour development. However, while siRNA and gene/antisense therapies provide alternatives to conventional chemotherapies, significant hurdles related to the delivery and efficacy of treatment must still be overcome before this technology can be used as an effective treatment for cancer and other diseases. This review highlights the issues associated with siRNA therapy in vivo, and describes the various approaches that are being explored using polymers as delivery vectors. In particular, the review focuses on targeted delivery as a means of improving efficacy of the gene therapy.
View less >
View more >One of the most promising routes for cancer therapy that has evolved over the previous decade is the use of small-interfering RNA (siRNA) as a means of switching off genes that are responsible for tumour development. However, while siRNA and gene/antisense therapies provide alternatives to conventional chemotherapies, significant hurdles related to the delivery and efficacy of treatment must still be overcome before this technology can be used as an effective treatment for cancer and other diseases. This review highlights the issues associated with siRNA therapy in vivo, and describes the various approaches that are being explored using polymers as delivery vectors. In particular, the review focuses on targeted delivery as a means of improving efficacy of the gene therapy.
View less >
Journal Title
Journal of Chemical Technology and Biotechnology
Subject
Cancer therapy (excl. chemotherapy and radiation therapy)