Multipotent cells from adult olfactory mucosa and their utility for tissue repair

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Title Multipotent cells from adult olfactory mucosa and their utility for tissue repair
Author Murrell, Wayne George; Wetzig, Andrew Roberts; Cameron, Nicholas; Splatt, Karisha Jade; Bianco, John Ivan; Perry, Christopher; Lee, Gabriel; Mackay-Sim, Alan
Publication Title Mechanisms of Development
Editor Patrick Tam
Year Published 2005
Place of publication Amsterdam, The Netherlands
Publisher Elsevier
Abstract Multipotent stem cells are thought to be responsible for the generation of new neurons in the adult brain. Neurogenesis also occurs in an accessible part of the nervous system, the olfactory mucosa. We show here that cells from human olfactory mucosa generate neurospheres that are multipotent in vitro and when transplanted into the chicken embryo. Cloned neurosphere cells show this multipotency. Multipotency was evident without prior culture in vitro: cells dissociated from adult rat olfactory mucosa generate leukocytes when transplanted into bone-marrow irradiated hosts and cells dissociated from adult mouse olfactory epithelium generated numerous cell types when transplanted into the chicken embryo. It is unlikely that these results can be attributed to hematopoietic precursor contamination or cell fusion. These results demonstrate the existence of a multipotent stem-like cell in the olfactory mucosa useful for autologous transplantation therapies and for cellular studies of disease. To date we have instigated two tissue repair strategies using olfactory stem cells and here report data generated from two pilot studies: those of a rat model of Parkinson's disease and of a rat model of cardiac infarct.
Peer Reviewed No
Published Yes
Publisher URI http://www.sciencedirect.com/science/journal/09254773
Alternative URI http://dx.doi.org/10.1016/j.mod.2005.06.010
ISBN 0925-4773
Conference name 15th International Society of Developmental Biologists Congress 2005
Location Sydney
Date From 2005-09-03
Date To 2005-09-07
URI http://hdl.handle.net/10072/9857
Date Accessioned 2006-02-24
Language en_AU
Research Centre Eskitis Institute for Drug Discovery
Faculty Faculty of Science
Subject PRE2009-Cell Development (incl. Cell Division and Apoptosis)
Publication Type Conference Publications (Extract Paper)
Publication Type Code e3

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